Abstract Interleukin-10 (IL-10), a cytokine with anti-inflammatory properties, has a central
role in infection by limiting the immune response to pathogens and thereby preventing …

Changes in mRNA stability and translation are critical control points in the regulation of gene
expression, particularly genes encoding growth factors, inflammatory mediators, and proto …

In macrophages detection of gram-negative bacteria particularly involves binding of the
outer-wall component lipopolysaccharide (LPS) to its cognate receptor complex, comprising …

The mitogen-activated protein kinase (MAPK) family includes the p38 kinases, which consist
of highly conserved proline-directed serine-threonine protein kinases that are activated in …

Abstract Interleukin (IL)-10 is an important immunoregulatory cytokine and an understanding
of how IL-10 expression is controlled is critical in the design of immune intervention …

Transcriptional control mechanisms chart the course of the inflammatory response by
synthesizing mRNAs encoding proteins that promote or inhibit inflammation. Because these …

Abstract Interleukin (IL)-10 is an essential anti-inflammatory cytokine that plays important
roles as a negative regulator of immune responses to microbial antigens. Loss of IL-10 …

Mitogen-activated protein kinase (MAPK) pathways are implicated in several cellular
processes including proliferation, differentiation, apoptosis, cell survival, cell motility …

mRNA turnover is a critical step in the control of gene expression. In mammalian cells, a
subset of mRNAs regulated at the level of mRNA turnover contain destabilizing AU-rich …

Background Birch bark has a long lasting history as a traditional medicinal remedy to
accelerate wound healing. Recently, the efficacy of birch bark preparations has also been …