Hippocampal GABAergic inhibitory interneurons
KA Pelkey, R Chittajallu, MT Craig… - Physiological …, 2017 - journals.physiology.org
In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …
of the total neuronal population; however, their remarkable anatomical and physiological …
Neonatal hypoxia ischaemia: mechanisms, models, and therapeutic challenges
LJ Millar, L Shi, A Hoerder-Suabedissen… - Frontiers in cellular …, 2017 - frontiersin.org
Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …
human neonates, and is often associated with persistent motor, sensory, and cognitive …
Novel stroke therapeutics: unraveling stroke pathophysiology and its impact on clinical treatments
PM George, GK Steinberg - Neuron, 2015 - cell.com
Stroke remains a leading cause of death and disability in the world. Over the past few
decades our understanding of the pathophysiology of stroke has increased, but greater …
decades our understanding of the pathophysiology of stroke has increased, but greater …
Human induced pluripotent stem cell-derived cortical neurons integrate in stroke-injured cortex and improve functional recovery
Stem cell-based approaches to restore function after stroke through replacement of dead
neurons require the generation of specific neuronal subtypes. Loss of neurons in the …
neurons require the generation of specific neuronal subtypes. Loss of neurons in the …
Cerebral ischemia and neuroregeneration
RHC Lee, MHH Lee, CYC Wu, AC e Silva… - Neural regeneration …, 2018 - journals.lww.com
Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide.
Although stroke (a form of cerebral ischemia)-related costs are expected to reach 240.67 …
Although stroke (a form of cerebral ischemia)-related costs are expected to reach 240.67 …
Synaptic inputs from stroke-injured brain to grafted human stem cell-derived neurons activated by sensory stimuli
D Tornero, O Tsupykov, M Granmo, C Rodriguez… - Brain, 2017 - academic.oup.com
Transplanted neurons derived from stem cells have been proposed to improve function in
animal models of human disease by various mechanisms such as neuronal replacement …
animal models of human disease by various mechanisms such as neuronal replacement …
Hydrogel matrix to support stem cell survival after brain transplantation in stroke
J Zhong, A Chan, L Morad… - … and neural repair, 2010 - journals.sagepub.com
Stroke is a leading cause of adult disability. Stem/progenitor cell transplantation improves
recovery after stroke in rodent models. These studies have 2 main limitations to clinical …
recovery after stroke in rodent models. These studies have 2 main limitations to clinical …
Delivery of iPS‐NPCs to the stroke cavity within a hyaluronic acid matrix promotes the differentiation of transplanted cells
J Lam, WE Lowry, ST Carmichael… - Advanced functional …, 2014 - Wiley Online Library
Stroke is the leading cause of adult disability with≈ 80% being ischemic. Stem cell
transplantation has been shown to improve functional recovery. However, the overall …
transplantation has been shown to improve functional recovery. However, the overall …
[HTML][HTML] Human neural stem cell grafts modify microglial response and enhance axonal sprouting in neonatal hypoxic–ischemic brain injury
Background and Purpose—Hypoxic–ischemic (HI) brain injury in newborn infants
represents a major cause of cerebral palsy, development delay, and epilepsy. Stem cell …
represents a major cause of cerebral palsy, development delay, and epilepsy. Stem cell …
Neurorestoration after stroke
TD Azad, A Veeravagu, GK Steinberg - Neurosurgical focus, 2016 - thejns.org
Recent advancements in stem cell biology and neuromodulation have ushered in a battery
of new neurorestorative therapies for ischemic stroke. While the understanding of stroke …
of new neurorestorative therapies for ischemic stroke. While the understanding of stroke …