Phase separation of signaling molecules promotes T cell receptor signal transduction
Activation of various cell surface receptors triggers the reorganization of downstream
signaling molecules into micrometer-or submicrometer-sized clusters. However, the …
signaling molecules into micrometer-or submicrometer-sized clusters. However, the …
Cytoskeletal control of B cell responses to antigens
P Tolar - Nature Reviews Immunology, 2017 - nature.com
The actin cytoskeleton is essential for cell mechanics and has increasingly been implicated
in the regulation of cell signalling. In B cells, the actin cytoskeleton is extensively coupled to …
in the regulation of cell signalling. In B cells, the actin cytoskeleton is extensively coupled to …
On the role of phase separation in the biogenesis of membraneless compartments
A Musacchio - The EMBO journal, 2022 - embopress.org
Molecular mechanistic biology has ushered us into the world of life's building blocks,
revealing their interactions in macromolecular complexes and inspiring strategies for …
revealing their interactions in macromolecular complexes and inspiring strategies for …
Stoichiometry controls activity of phase-separated clusters of actin signaling proteins
Biomolecular condensates concentrate macromolecules into foci without a surrounding
membrane. Many condensates appear to form through multivalent interactions that drive …
membrane. Many condensates appear to form through multivalent interactions that drive …
Phase transitions of multivalent proteins can promote clustering of membrane receptors
Clustering of proteins into micrometer-sized structures at membranes is observed in many
signaling pathways. Most models of clustering are specific to particular systems, and …
signaling pathways. Most models of clustering are specific to particular systems, and …
An optimized optogenetic clustering tool for probing protein interaction and function
The Arabidopsis photoreceptor cryptochrome 2 (CRY2) was previously used as an
optogenetic module, allowing spatiotemporal control of cellular processes with light. Here …
optogenetic module, allowing spatiotemporal control of cellular processes with light. Here …
Principles of self-organization and load adaptation by the actin cytoskeleton during clathrin-mediated endocytosis
Force generation by actin assembly shapes cellular membranes. An experimentally
constrained multiscale model shows that a minimal branched actin network is sufficient to …
constrained multiscale model shows that a minimal branched actin network is sufficient to …
Conserved interdomain linker promotes phase separation of the multivalent adaptor protein Nck
The organization of membranes, the cytosol, and the nucleus of eukaryotic cells can be
controlled through phase separation of lipids, proteins, and nucleic acids. Collective …
controlled through phase separation of lipids, proteins, and nucleic acids. Collective …
Mathematical modeling of eukaryotic cell migration: insights beyond experiments
A migrating cell is a molecular machine made of tens of thousands of short-lived and
interacting parts. Understanding migration means understanding the self-organization of …
interacting parts. Understanding migration means understanding the self-organization of …
[HTML][HTML] Drops and fibers—how biomolecular condensates and cytoskeletal filaments influence each other
The cellular cytoskeleton self-organizes by specific monomer–monomer interactions
resulting in the polymerization of filaments. While we have long thought about the role of …
resulting in the polymerization of filaments. While we have long thought about the role of …