Neuroinflammation PET imaging of the translocator protein (TSPO) in Alzheimer's disease: an update

D Gouilly, L Saint‐Aubert, MJ Ribeiro… - European Journal of …, 2022 - Wiley Online Library
Neuroinflammation is a significant contributor to Alzheimer's disease (AD). Until now, PET
imaging of the translocator protein (TSPO) has been widely used to depict the neuroimmune …

The role of translocator protein TSPO in hallmarks of glioblastoma

LM Ammer, A Vollmann-Zwerenz, V Ruf, CH Wetzel… - Cancers, 2020 - mdpi.com
Simple Summary The translocator protein (TSPO) has been under extensive investigation as
a specific marker in positron emission tomography (PET) to visualize brain lesions following …

Neuroinflammation after COVID-19 with persistent depressive and cognitive symptoms

J Braga, M Lepra, SJ Kish, PM Rusjan, Z Nasser… - JAMA …, 2023 - jamanetwork.com
Importance Persistent depressive symptoms, often accompanied by cognitive symptoms,
commonly occur after COVID-19 illness (hereinafter termedCOVID-DC, DC for depressive …

Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia

R Bonomi, AT Hillmer, E Woodcock, S Bhatt… - Proceedings of the …, 2024 - pnas.org
Dynamic brain immune function in individuals with posttraumatic stress disorder is rarely
studied, despite evidence of peripheral immune dysfunction. Positron emission tomography …

Microglia as therapeutic target for radiation-induced brain injury

Q Liu, Y Huang, M Duan, Q Yang, B Ren… - International journal of …, 2022 - mdpi.com
Radiation-induced brain injury (RIBI) after radiotherapy has become an increasingly
important factor affecting the prognosis of patients with head and neck tumor. With the …

18F-Radiolabeled Translocator Protein (TSPO) PET Tracers: Recent Development of TSPO Radioligands and Their Application to PET Study

TG Luu, HK Kim - Pharmaceutics, 2022 - mdpi.com
Translocator protein 18 kDa (TSPO) is a transmembrane protein in the mitochondrial
membrane, which has been identified as a peripheral benzodiazepine receptor. TSPO is …

[HTML][HTML] Sickness behaviour and depression: An updated model of peripheral-central immunity interactions

FE Turkheimer, M Veronese, V Mondelli, D Cash… - Brain, Behavior, and …, 2023 - Elsevier
Current research into mood disorders indicates that circulating immune mediators
participating in the pathophysiology of chronic somatic disorders have potent influences on …

Intervention of neuroinflammation in the traumatic brain injury trajectory: In vivo and clinical approaches

NK Prabhakar, H Khan, AK Grewal, TG Singh - International …, 2022 - Elsevier
TBI has been one of the top causes of death and morbidity worldwide, yet despite enormous
efforts to discover neuroprotective therapeutics for this serious disease, no beneficial …

[HTML][HTML] Combination treatment with radiotherapy and a novel oxidative phosphorylation inhibitor overcomes PD-1 resistance and enhances antitumor immunity

D Chen, HB Barsoumian, G Fischer… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Despite outstanding responses to anti-PD-1 agents in a subset of non-small cell
lung cancer (NSCLC) patients, approximately 80% of patients fail to have prolonged …

Neuroimmunology of rabies: New insights into an ancient disease

V Bastos, V Pacheco, ÉDL Rodrigues… - Journal of Medical …, 2023 - Wiley Online Library
Rabies is an ancient neuroinvasive viral (genus Lyssavirus, family Rhabdoviridae) disease
affecting approximately 59,000 people worldwide. The central nervous system (CNS) is …