Thirst motivates animals to find and consume water. More than 40 years ago, a set of
interconnected brain structures known as the lamina terminalis was shown to govern thirst …

Thirst is important for maintaining body fluid homeostasis and may arise from deficits in
either intracellular or extracellular fluid volume. Neural signals arising from osmotic and …

The detection of osmotic stimuli is essential for all organisms, yet few osmoreceptive
proteins are known, none of them in vertebrates. By employing a candidate-gene approach …

The brain's three sensory circumventricular organs, the subfornical organ, organum
vasculosum of the lamina terminalis and the area postrema lack a blood brain barrier and …

Located in the midline anterior wall of the third cerebral ventricle (ie the lamina terminalis),
the median preoptic nucleus (Mn PO) receives a unique set of afferent neural inputs from …

Neural circuits for appetites are regulated by both homeostatic perturbations and ingestive
behaviour. However, the circuit organization that integrates these internal and external …

Hypernatremia is defined as a serum sodium level above 145 mmol/L. It is a frequently
encountered electrolyte disturbance in the hospital setting, with an unappreciated high …

Circumventricular organs (CVO) play a critical role as transducers of information between
the blood, neurons and the cerebral spinal fluid (CSF). They permit both the release and …

The lamina terminalis, located in the anterior wall of the third ventricle, is comprised of the
subfornical organ, median preoptic nucleus (MnPO) and organum vasculosum of the lamina …

Sensory circumventricular organs (CVOs) are specialized areas of the brain that lack a
normal blood–brain barrier, and therefore are in constant contact with signaling molecules …