Frailty and the management of hematologic malignancies

GA Abel, HD Klepin - Blood, The Journal of the American …, 2018 - ashpublications.org
The majority of blood cancers occur in the elderly. This fact conspires with an aging
population in many countries to make rigorous assessment for frailty increasingly important …

Use of geriatric assessment for older adults in the oncology setting: a systematic review

MTE Puts, J Hardt, J Monette, V Girre… - Journal of the …, 2012 - academic.oup.com
Background Geriatric assessment is a multidisciplinary diagnostic process that evaluates the
older adult's medical, psychological, social, and functional capacity. No systematic review of …

Practical assessment and management of vulnerabilities in older patients receiving chemotherapy: ASCO guideline for geriatric oncology

SG Mohile, W Dale, MR Somerfield… - Journal of clinical …, 2018 - ascopubs.org
Purpose To provide guidance regarding the practical assessment and management of
vulnerabilities in older patients undergoing chemotherapy. Methods An Expert Panel was …

Simplified geriatric assessment in older patients with diffuse large B-cell lymphoma: the prospective elderly project of the Fondazione Italiana Linfomi

F Merli, S Luminari, A Tucci, A Arcari… - Journal of clinical …, 2021 - ascopubs.org
PURPOSE To prospectively validate the use of a simplified geriatric assessment (sGA) at
diagnosis and to integrate it into a prognostic score for older patients with diffuse large B-cell …

Attenuated immunochemotherapy regimen (R-miniCHOP) in elderly patients older than 80 years with diffuse large B-cell lymphoma: a multicentre, single-arm, phase 2 …

F Peyrade, F Jardin, C Thieblemont, A Thyss… - The Lancet …, 2011 - thelancet.com
Background Diffuse large B-cell lymphoma is a common cancer in elderly patients. Although
treatment has been standardised in younger patients, no prospective study has been done …

Gait speed, grip strength, and clinical outcomes in older patients with hematologic malignancies

MA Liu, C DuMontier, A Murillo… - Blood, The Journal …, 2019 - ashpublications.org
This study aimed to evaluate whether gait speed and grip strength predicted clinical
outcomes among older adults with blood cancers. We prospectively recruited 448 patients …

End points and trial design in geriatric oncology research: a joint European organisation for research and treatment of cancer–Alliance for Clinical Trials in Oncology …

H Wildiers, M Mauer, A Pallis, A Hurria… - Journal of Clinical …, 2013 - ascopubs.org
Selecting the most appropriate end points for clinical trials is important to assess the value of
new treatment strategies. Well-established end points for clinical research exist in oncology …

Implementing a geriatric assessment in cooperative group clinical cancer trials: CALGB 360401

A Hurria, CT Cirrincione, HB Muss… - Journal of clinical …, 2011 - ascopubs.org
Purpose Factors captured in a geriatric assessment can predict morbidity and mortality in
older adults, but are not routinely measured in cancer clinical trials. This study evaluated the …

Older adults with cancer and their caregivers—current landscape and future directions for clinical care

S Kadambi, KP Loh, R Dunne, A Magnuson… - Nature Reviews …, 2020 - nature.com
Despite substantial improvements in the outcomes of patients with cancer over the past two
decades, older adults (aged≥ 65 years) with cancer are a rapidly increasing population and …

Evaluating the older patient with cancer: understanding frailty and the geriatric assessment

SK Pal, V Katheria, A Hurria - CA: a cancer journal for clinicians, 2010 - Wiley Online Library
The majority of cancer incidence and mortality occurs in individuals aged older than 65
years, and the number of older adults with cancer is projected to significantly increase …