Importance More than 42 000 Americans died of opioid overdoses in 2016, and the fatalities
continue to increase. This review analyzes the factors that triggered the opioid crisis and its …

Relationship between Nonmedical Prescription-Opioid Use and Heroin Use | New England
Journal of Medicine Skip to main content Access provided byTE WHATU ORA HEALTH NEW …

INTRODUCTION The epidemic of substance use disorders and drug overdose deaths is a
growing public health crisis in the United States. Every day, 174 people die from drug …

Chronic pain and prescription opioid abuse are extremely prevalent both in this country and
worldwide. Consequences of opioid misuse can be life-threatening with significant morbidity …

Importance Health profiles and patterns of involvement in the criminal justice system among
people with various levels of opioid use are poorly defined. Data are needed to inform a …

Objective: Increasing rates of opioid use disorders (OUDs)(abuse and dependence) among
patients prescribed opioids are a significant public health concern. We investigated the …

This analysis confirms the predominant role opioid analgesics play in pharmaceutical
overdose deaths, either alone or in combination with other drugs. It also, however, highlights …

This paper reviews studies examining the pharmacological interactions and epidemiology of
the combined use of opioids and benzodiazepines (BZDs). A search of English language …

Background Heroin use and overdose deaths have increased in recent years. Emerging
information suggests this is the result of increases in nonmedical use of opioid pain relievers …

Importance Current approaches to identifying individuals at high risk for opioid overdose
target many patients who are not truly at high risk. Objective To develop and validate a …