Transforming growth factor-β (TGF-β) signaling regulates cell-specific programs involved in
embryonic development, wound-healing, and immune homeostasis. Yet, during tumor …

Simple Summary Macrophages that infiltrate the cancer microenvironment are referred to as
tumor-associated macrophages (TAMs). Phosphoprotein 1 (SPP1), also known as …

Despite the challenges posed by drug resistance and side effects, chemotherapy remains a
pivotal strategy in cancer treatment. A key issue in this context is macroautophagy …

High-grade serous ovarian cancer (HGSOC) is notoriously known as the “silent killer” of post-
menopausal women as it has an insidious progression and is the deadliest gynaecological …

Epithelial ovarian cancer (EOC) is considered the deadliest gynecological disease and is
normally diagnosed at late stages, at which point metastasis has already occurred …

Despite significant advances in the understanding of cancer biology, cancer is still a leading
cause of death worldwide. Expression of the tumor microenvironment component …

Simple Summary Studies have shown that SPP1 plays an important role in the progression
of certain tumors, but the specific functional mechanism in gastric cancer (GC) is still unclear …

Ovarian cancer (OvCa), a lethal gynecological malignancy, disseminates to the peritoneum.
Mesothelial cells (MCs) act as barriers in the abdominal cavity, preventing the adhesion of …

Ovarian cancer (OvCa) preferentially metastasizes in association with mesothelial cell–lined
surfaces. We sought to determine if mesothelial cells are required for OvCa metastasis and …

Cancer-associated mesothelial cells (CAMCs) in the tumor microenvironment are thought to
promote growth and immune evasion. We find that, in mouse and human ovarian tumors …