[HTML][HTML] TGF-β, EMT, and resistance to anti-cancer treatment
X Wang, PJA Eichhorn, JP Thiery - Seminars in Cancer Biology, 2023 - Elsevier
Transforming growth factor-β (TGF-β) signaling regulates cell-specific programs involved in
embryonic development, wound-healing, and immune homeostasis. Yet, during tumor …
embryonic development, wound-healing, and immune homeostasis. Yet, during tumor …
The significance of SPP1 in lung cancers and its impact as a marker for protumor tumor-associated macrophages
E Matsubara, H Yano, C Pan, Y Komohara, Y Fujiwara… - Cancers, 2023 - mdpi.com
Simple Summary Macrophages that infiltrate the cancer microenvironment are referred to as
tumor-associated macrophages (TAMs). Phosphoprotein 1 (SPP1), also known as …
tumor-associated macrophages (TAMs). Phosphoprotein 1 (SPP1), also known as …
[HTML][HTML] Autophagy-driven regulation of cisplatin response in human cancers: exploring molecular and cell death dynamics
Y Yang, L Liu, Y Tian, M Gu, Y Wang, M Ashrafizadeh… - Cancer Letters, 2024 - Elsevier
Despite the challenges posed by drug resistance and side effects, chemotherapy remains a
pivotal strategy in cancer treatment. A key issue in this context is macroautophagy …
pivotal strategy in cancer treatment. A key issue in this context is macroautophagy …
[HTML][HTML] Extracellular matrix in high-grade serous ovarian cancer: Advances in understanding of carcinogenesis and cancer biology
High-grade serous ovarian cancer (HGSOC) is notoriously known as the “silent killer” of post-
menopausal women as it has an insidious progression and is the deadliest gynaecological …
menopausal women as it has an insidious progression and is the deadliest gynaecological …
The transcoelomic ecosystem and epithelial ovarian cancer dissemination
SJ Ritch, CM Telleria - Frontiers in Endocrinology, 2022 - frontiersin.org
Epithelial ovarian cancer (EOC) is considered the deadliest gynecological disease and is
normally diagnosed at late stages, at which point metastasis has already occurred …
normally diagnosed at late stages, at which point metastasis has already occurred …
Osteopontin in cancer: mechanisms and therapeutic targets
Y Kariya, Y Kariya - International Journal of Translational Medicine, 2022 - mdpi.com
Despite significant advances in the understanding of cancer biology, cancer is still a leading
cause of death worldwide. Expression of the tumor microenvironment component …
cause of death worldwide. Expression of the tumor microenvironment component …
Multi-transcriptomic analysis reveals the heterogeneity and tumor-promoting role of SPP1/CD44-mediated intratumoral crosstalk in gastric cancer
W Xie, J Cheng, Z Hong, W Cai, H Zhuo, J Hou, L Lin… - Cancers, 2022 - mdpi.com
Simple Summary Studies have shown that SPP1 plays an important role in the progression
of certain tumors, but the specific functional mechanism in gastric cancer (GC) is still unclear …
of certain tumors, but the specific functional mechanism in gastric cancer (GC) is still unclear …
Peritoneal restoration by repurposing vitamin D inhibits ovarian cancer dissemination via blockade of the TGF-β1/thrombospondin-1 axis
K Kitami, M Yoshihara, S Tamauchi, M Sugiyama… - Matrix Biology, 2022 - Elsevier
Ovarian cancer (OvCa), a lethal gynecological malignancy, disseminates to the peritoneum.
Mesothelial cells (MCs) act as barriers in the abdominal cavity, preventing the adhesion of …
Mesothelial cells (MCs) act as barriers in the abdominal cavity, preventing the adhesion of …
[HTML][HTML] Cancer-associated mesothelial cell–derived ANGPTL4 and STC1 promote the early steps of ovarian cancer metastasis
P Bajwa, K Kordylewicz, A Bilecz, RR Lastra… - JCI insight, 2023 - ncbi.nlm.nih.gov
Ovarian cancer (OvCa) preferentially metastasizes in association with mesothelial cell–lined
surfaces. We sought to determine if mesothelial cells are required for OvCa metastasis and …
surfaces. We sought to determine if mesothelial cells are required for OvCa metastasis and …
[HTML][HTML] Cancer-associated mesothelial cells are regulated by the anti-Müllerian hormone axis
Cancer-associated mesothelial cells (CAMCs) in the tumor microenvironment are thought to
promote growth and immune evasion. We find that, in mouse and human ovarian tumors …
promote growth and immune evasion. We find that, in mouse and human ovarian tumors …