Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a
common chronic pain condition with major impact on quality of life. Examples include …

Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …

Neuropathic pain is caused by a lesion or disease of the somatosensory system, including
peripheral fibres (Aβ, Aδ and C fibres) and central neurons, and affects 7–10% of the …

Voltage-gated sodium (Nav) channels are targeted by a number of widely used and
investigational drugs for the treatment of epilepsy, arrhythmia, pain, and other disorders …

The trigeminal nerve (V) is the fifth and largest of all cranial nerves, and it is responsible for
detecting sensory stimuli that arise from the craniofacial area. The nerve is divided into three …

Pre-diabetes and diabetes are a global epidemic, and the associated neuropathic
complications create a substantial burden on both the afflicted patients and society as a …

Small fibre neuropathies are a heterogeneous group of disorders affecting thinly myelinated
Aδ-fibres and unmyelinated C-fibres. Although multiple causes of small nerve fibre …

The effective and safe treatment of pain is an unmet health-care need. Current medications
used for pain management are often only partially effective, carry dose-limiting adverse …

Fibromyalgia is a disorder that is part of a spectrum of syndromes that lack precise
classification. It is often considered as part of the global overview of functional somatic …

Peripheral nerve injury could lead to chronic neuropathic pain. Understanding
transcriptional changes induced by nerve injury could provide fundamental insights into the …