Photoactivatable (alternatively, photoremovable, photoreleasable, or photocleavable)
protecting groups (PPGs), also known as caged or photocaged compounds, are used to …

Metal ions are essential to many chemical, biological, and environmental processes. In the
past two decades, many DNA-based metal sensors have emerged. While the main …

Biological signalling is regulated through a complex and tightly choreographed interplay
between cells and their extracellular matrix. The spatiotemporal control of these interactions …

This review article introduces mechanistic aspects and applications of photochemically
deprotected ortho-nitrobenzyl (ONB)-functionalized nucleic acids and their impact on …

Biological processes are naturally regulated with high spatial and temporal control, as is
perhaps most evident in metazoan embryogenesis. Chemical tools have been extensively …

Light is a uniquely powerful tool for controlling molecular events in biology. No other
external input (eg, heat, ultrasound, magnetic field) can be so tightly focused or so highly …

In the two decades since the introduction of the “click chemistry” concept, the toolbox of “click
reactions” has continually expanded, enabling chemists, materials scientists, and biologists …

RNA-binding proteins (RBPs) play an essential role in regulating the function of RNAs in a
cellular context, but our ability to control RBP activity in time and space is limited. Here, we …

Despite the pre-eminence of the mouse in modelling human disease, several aspects of
murine biology limit its routine use in large-scale genetic and therapeutic screening. Many …

Zebrafish (Danio rerio) has been a prominent model vertebrate in a variety of biological
disciplines. Substantial information gathered from developmental and genetic research …