Nitrogen (N) is widely distributed in the lithosphere, hydrosphere, atmosphere and
biosphere. It is a basic component of every plant cell as well as microorganisms, as a …

The human major histocompatibility complex is a family of genes that encodes HLAs, which
have a crucial role in defence against foreign pathogens and immune surveillance of …

Preexisting humoral immunity to recombinant adeno-associated virus (AAV) vectors restricts
the treatable patient population and efficacy of human gene therapies. Approaches to clear …

The Streptococcus pneumoniae capsule is vital for virulence and may inhibit complement
activity and phagocytosis. However, there are only limited data on the mechanisms by which …

Abstract The neonatal FcR (FcRn) binds to the Fc domain of IgG at acidic pH in the
endosome and protects IgG from degradation, thereby contributing to the long serum half-life …

Objectives: The presence of a donor-specific positive crossmatch has been considered to be
a contraindication to kidney transplantation because of the risk of hyperacute rejection …

Safety, immunogenicity, pharmacokinetics, and efficacy of the IgG-degrading enzyme of
Streptococcus pyogenes (IdeS [imlifidase]) were assessed in a single-center, open-label …

IdeS is a streptococcal protease that cleaves IgG antibodies into F (ab') 2 and Fc fragments
with a unique degree of specificity, thereby providing a novel treatment opportunity of IgG …

Despite the success of desensitization protocols, antibody-mediated rejection (AMR)
remains a significant contributor to renal allograft failure in patients with donor-specific …

One of the major goals of in vivo gene transfer is to achieve long-term expression of
therapeutic transgenes in terminally differentiated cells. The extensive clinical experience …