Hypoxia is an integral component of the tumor microenvironment. Either as chronic or
cycling hypoxia, it exerts a similar effect on cancer processes by activating hypoxia-inducible …

This paper reports a polydimethylsiloxane–polycarbonate (PDMS–PC) hybrid microfluidic
device capable of performing cell culture under combinations of chemical and oxygen …

Hypoxia induces protective autophagy in advanced glioblastoma cells, and targeting this
process may improve the outcome for glioblastoma patients. Recent studies have suggested …

Bone marrow mesenchymal stem cells (BMSCs), as seed cells, have played an important
role in bone defect repair. However, efficiently amplifying and inducing BMSCs in vitro or …

Stromal cell-derived factor-1α (SDF-1α) and its chemokine receptor 4 (CXCR4) play an
important role in regulating bone marrow stromal stem cells (BMSCs) migration, proliferation …

Background Leukemic cells originate from hypoxic bone marrow, which protects them from
anti-cancer drugs. Although many factors that cause drug resistance in leukemic cells have …

The mechanisms by which cells undergo proliferation arrest or cell death in response to
hypoxia are still not completely understood. Originally, we showed that HeLa and Hep3B …

Bacterial pathogens employ several strategies to dampen host cell immune responses. In
this work we studied a secreted effector protein of the Yersinia pseudotuberculosis type …