Microglia are the main immune cells in the brain, playing a role in both physiological and
pathological conditions. Microglial involvement in neurodegenerative diseases is well …

Viral vectors are becoming increasingly important tools to investigate the function of neural
proteins and to explore the feasibility of gene therapy to treat diseases of the nervous …

Neurotrophic factors that improve the survival of specific neuronal types during development
and after exposure to various neuronal insults hold potential for treatment of …

Glial cell line‐derived neurotrophic factor (GDNF) has been shown to increase the survival
of dopamine neurons in a variety of in vitro and in vivo model systems. Therefore, it …

Primary astrocytes were genetically modified ex vivo to express recombinant glial cell line-
derived neurotrophic factor (GDNF) and subsequently were tested for their ability to provide …

Environment, training, and experience can influence plasticity and recovery of function after
brain damage. However, it is less well known whether, and how, such factors influence the …

Parkinson'disease (PD) is a most common and debilitating degenerative disease resulted
from massive loss of dopamine neurons in the substantia nigra pars compacta, which is …

The use of primary human fetal tissue in the treatment of neurodegenerative disorders, while
promising, faces several difficult technical and ethical issues. An alternative approach that …

Parkinson's disease is a neurodegenerative disorder characterized by the depletion of
dopamine in the caudate putamen. Dopamine replacement with levodopa, a precursor of the …

The transplantation of genetically modified cells represents one potential means of
delivering trophic factors to the brain to support the survival of host neurons and to increase …