Mineralocorticoid receptor (MR) activation is involved in propagating kidney injury,
inflammation, and fibrosis and in the progression of chronic kidney disease (CKD). Multiple …

Regulation and action of the mineralocorticoid receptor (MR) have been the focus of
intensive research over the past 80 years. Genetic and physiological/biochemical analysis …

Hypertension and its comorbidities pose a major public health problem associated with
disease-associated factors related to a modern lifestyle, such high salt intake or obesity …

The kidney plays a crucial role in acid-base homeostasis. In the distal nephron, α-
intercalated cells contribute to urinary acid (H+) secretion and β-intercalated cells …

The Cl−/HCO 3− exchanger pendrin in the kidney maintains acid-base balance and
intravascular volume. Pendrin is upregulated in models associated with high circulating …

Pendrin is a Cl−/HCO3− exchanger selectively present in the intercalated cells of the kidney.
Although experimental studies have demonstrated that pendrin regulates blood pressure …

The kidney plays a key role in the correction of systemic acid-base imbalances. Central for
this regulation are the intercalated cells in the distal nephron, which secrete acid or base …

The past 90 years have witnessed an extraordinary trajectory of scientific discovery relating
to aldosterone and mineralocorticoid receptor (MR) activation, and a profound reappraisal of …

Intercalated cells make up about a third of all cells within the connecting tubule and the
collecting duct and are subclassified as type A, type B and non-A, non-B based on the …

In 2009, two groups independently linked human mutations in the inwardly rectifying K+
channel Kir4. 1 (gene name KCNJ10) to a syndrome affecting the central nervous system …