Antiseizure drugs (ASDs) prevent the occurrence of seizures; there is no evidence that they
have disease-modifying properties. In the more than 160 years that orally administered …

In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

Understanding the organizational logic of neural circuits requires deciphering the biological
basis of neuronal diversity and identity, but there is no consensus on how neuron types …

Background Post-partum depression is a serious mood disorder in women that might be
triggered by peripartum fluctuations in reproductive hormones. This phase 2 study …

The pathophysiology of major depressive disorder (MDD) is thought to result from impaired
connectivity between key brain networks. Gamma-aminobutyric acid (GABA) is the key …

The central amygdala (CeA) plays a central role in physiologic and behavioral responses to
fearful stimuli, stressful stimuli, and drug-related stimuli. The CeA receives dense inputs from …

Positive allosteric modulators of γ-aminobutyric acid-A (GABA A) receptors or GABAkines
have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other …

Intellectual disability, autism spectrum disorder, and epilepsy are prime examples of
neurodevelopmental disorders that collectively affect a significant percentage of the world …

Progesterone is commonly considered as a female reproductive hormone and is well-known
for its role in pregnancy. It is less well appreciated that progesterone and its metabolite …

Abstract Zuranolone (SAGE-217) is a novel, synthetic, clinical stage neuroactive steroid
GABA A receptor positive allosteric modulator designed with the pharmacokinetic properties …