Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery
drive cell division. Growing evidence indicates that this machinery operates in a distinct …

The nucleus is the largest organelle and is commonly depicted in the center of the cell. Yet
during cell division, migration, and differentiation, it frequently moves to an asymmetric …

The assembly of cortical circuits involves the generation and migration of interneurons from
the ventral to the dorsal forebrain,–, which has been challenging to study at inaccessible …

Abstract p27 binds and inhibits cyclin-CDK to arrest the cell cycle. p27 also regulates other
processes including cell migration and development independent of its cyclin-dependent …

A fundamental question in neurobiology is how the balance between proliferation and
differentiation of neuronal precursors is maintained to ensure that the proper number of …

The emergence of functional neuronal connectivity in the developing cerebral cortex
depends on neuronal migration. This process enables appropriate positioning of neurons …

A wide spectrum of focal, regional, or diffuse structural brain abnormalities, collectively
known as malformations of cortical development (MCDs), frequently manifest with …

Cyclin‐dependent kinases (CDK s) generally regulate cell proliferation in dividing cells,
including neural progenitors. In contrast, an unconventional CDK, C dk5, is predominantly …

Most neurons migrate with an elongated,“bipolar” morphology, extending a long leading
process that explores the environment. However, when immature projection neurons enter …

The mammalian brain consists of numerous compartments that are closely connected with
each other via neural networks, comprising the basis of higher order brain functions. The …