The alterations in myocardial energy substrate metabolism that occur in heart failure, and
the causes and consequences of these abnormalities, are poorly understood. There is …

Reperfusion of the heart after a period of ischaemia leads to the opening of a nonspecific
pore in the inner mitochondrial membrane, known as the mitochondrial permeability …

The aim of this study was to investigate the effect of Krebs cycle intermediates on basal and
quinolinic acid (QA)-or iron-induced TBARS production in brain membranes. Oxaloacetate …

Leakage of mitochondrial oxidants contributes to a variety of harmful conditions ranging from
neurodegenerative diseases to cellular senescence. We describe here, however, a …

A prolonged period of ischaemia followed by reperfusion irreversibly damages the heart.
Such reperfusion injury (RI) involves opening of the mitochondrial permeability transition …

The chronically failing heart has been shown to be metabolically abnormal, in both animal
models and in patients. Little data are available on the rate of myocardial glucose, lactate …

Pyruvate is included in the energy production of the heart muscle and is metabolized into
lactate, alanine, and CO2 in equilibrium with HCO. The aim of this study was to evaluate the …

BACKGROUND AND PURPOSE: The present study was performed to test the hypothesis
that lactate accumulation correlates with the radioresistance of malignant tumors due to the …

Hyperpolarization of spins via dynamic nuclear polarization (DNP) has been explored as a
method to non‐invasively study real‐time metabolic rocesses occurring in vivo using 13C …

Magnetic resonance imaging (MRI) is the only imaging modality that can deliver information
about the molecular structure of an injected compound. Unfortunately, MRI has a relatively …