Niacin modulates depressive-like behavior in experimental colitis through GPR109A-dependent mechanisms
Aims Depression is one of the common neurological comorbidities in patients with
inflammatory bowel disease (IBD). The current study aimed to investigate the potential …
inflammatory bowel disease (IBD). The current study aimed to investigate the potential …
[HTML][HTML] The immunomodulatory effects of probiotics and azithromycin in dextran sodium sulfate-induced ulcerative colitis in rats via TLR4-NF-κB and p38-MAPK …
SE Elkholy, SA Maher, NR Abd El-Hamid… - Biomedicine & …, 2023 - Elsevier
Ulcerative colitis (UC), a chronic autoimmune disease of the gut with a relapsing and
remitting nature, considers a major health-care problem. DSS is a well-studied …
remitting nature, considers a major health-care problem. DSS is a well-studied …
Antiulcerogenic effect of melittin via mitigating TLR4/TRAF6 mediated NF-κB and p38MAPK pathways in acetic acid-induced ulcerative colitis in mice
Ulcerative colitis (UC) is a chronic disease driven primarily by uncontrolled pervasive
inflammatory responses affecting the colon and rectum. Currently available medications …
inflammatory responses affecting the colon and rectum. Currently available medications …
Anticolitic activity of prodigiosin loaded with selenium nanoparticles on acetic acid–induced colitis in rats
RB Kassab, M Elbaz, AAA Oyouni, AH Mufti… - … Science and Pollution …, 2022 - Springer
Ulcerative colitis (UC) is a chronic autoimmune inflammatory disease associated with
extensive mucosal damage. Prodigiosins (PGs) are natural bacterial pigments with well …
extensive mucosal damage. Prodigiosins (PGs) are natural bacterial pigments with well …
Naphthoquinone derivatives as P-glycoprotein inducers in inflammatory bowel disease: 2D monolayers, 3D spheroids, and in vivo models
N Mahmoud, MEF Hegazy, W Wadie… - Pharmacological …, 2022 - Elsevier
Inflammatory bowel disease (IBD) represents a chronic inflammation of the gastrointestinal
tract characterized by an overreaction of immune responses and damage at the intestinal …
tract characterized by an overreaction of immune responses and damage at the intestinal …
Imatinib mitigates experimentally-induced ulcerative colitis: Possible contribution of NF-kB/JAK2/STAT3/COX2 signaling pathway
Rationale Ulcerative colitis (UC) is a chronic immune-mediated disease characterized by
recurrent inflammation, damage, and alteration of the large intestine's mucosal and …
recurrent inflammation, damage, and alteration of the large intestine's mucosal and …
Donepezil halts acetic acid-induced experimental colitis in rats and its associated cognitive impairment through regulating inflammatory/oxidative/apoptotic cascades …
Ulcerative colitis (UC) is a persistent inflammatory bowel disease (IBD) that is regarded as a
risk factor for cognitive impairment. Donepezil (DON), a centrally acting acetylcholinesterase …
risk factor for cognitive impairment. Donepezil (DON), a centrally acting acetylcholinesterase …
Crosstalk between SIRT1/Nrf2 signaling and NLRP3 inflammasome/pyroptosis as a mechanistic approach for the neuroprotective effect of linagliptin in Parkinson's …
WZ Ghaith, W Wadie, MF El-Yamany - International Immunopharmacology, 2025 - Elsevier
In recent years, special attention has been paid to highlighting the antiparkinsonian effect of
linagliptin. However, the mechanism of its action has not yet been well investigated. The …
linagliptin. However, the mechanism of its action has not yet been well investigated. The …
Molsidomine alleviates acetic acid-induced colitis in rats by reducing oxidative stress, inflammation and apoptosis
NI Mohamed, GM Suddek, DH El-Kashef - International …, 2021 - Elsevier
Ulcerative colitis (UC) is a subcategory of intestinal inflammatory bowel disease
characterized by up-regulation of proinflammatory cytokines and oxidative stress. The …
characterized by up-regulation of proinflammatory cytokines and oxidative stress. The …
Diosmin-loaded Lipid chitosan hybrid nanoparticles boost the anti-inflammatory, antioxidant, and protective effect against acetic acid-induced colitis in rodents
WE Abd El Hady, ME Abdelmageed… - Journal of Drug Delivery …, 2024 - Elsevier
Diosmin showed poor water solubility and decreased bioavailability. The current study aims
to repurpose diosmin-loaded nanoparticles (LCHNps) to provide an alternative for the cure …
to repurpose diosmin-loaded nanoparticles (LCHNps) to provide an alternative for the cure …