Berberine, a bioactive alkaloid isolated from several herbal substances, possesses multiple
pharmacological effects, including antimicrobial, antidiabetic, anticancer activities …

The topoisomerase enzymes play an important role in DNA metabolism, and searching for
enzyme inhibitors is an important target in the search for new anticancer drugs. Discovery of …

Chemical compounds derived from plants have been used since the origin of human beings
to counteract a number of diseases. Among them, the natural isoquinoline alkaloid …

Natural products or nutraceuticals have been shown to elicit anti-aging, anti-cancer and
other health-enhancing effects. A key target of the effects of natural products may be the …

Alkaloids are used in traditional medicine for the treatment of many diseases. These
compounds are synthesized in plants as secondary metabolites and have multiple effects on …

Natural products represent a rich reservoir of potential small chemical molecules exhibiting
antiproliferation and anticancer properties. An example is berberine, a protoberberine …

This contribution reviews some general aspects of the quaternary iminium protoberberine
alkaloids. The alkaloids represent a very extensive group of secondary metabolites with …

Isoquinoline alkaloids-enriched herbal plants have been used as traditional folk medicine
for their anti-inflammatory, antimicrobial, and analgesic effects. They induce cell cycle arrest …

Berberine, a naturally occurring isoquinoline alkaloid, has been shown to possess anti-
inflammatory and antitumor properties in some in vitro systems. Here, we report that in vitro …

Isoquinoline alkaloids represent a group of natural products with remarkable importance in
the contemporary biomedical research and drug discovery programs. Several members of …