Although recent technical advances in thrombectomy have revolutionised acute stroke
treatment, prevalence of disability and death related to stroke remain high. Therefore …

The extracellular matrix (ECM) is a biological substrate composed of collagens,
proteoglycans and glycoproteins that ensures proper cell migration and adhesion and keeps …

Autophagy of mitochondria, termed mitophagy, plays an important role in cerebral ischemia-
reperfusion (IR) injury, but the mechanism is not yet clear. Tissue-type plasminogen activator …

Stroke is the world's second leading cause of mortality, with a high incidence of morbidity.
Numerous neuronal membrane receptors are activated by endogenous ligands and may …

One of the most intriguing features of the brain is its ability to be malleable, allowing it to
adapt continually to changes in the environment. Specific neuronal activity patterns drive …

The neurovascular unit (NVU) is assembled by endothelial cells (ECs) and pericytes, and
encased by a basement membrane (BM) surveilled by microglia and surrounded by …

The low-density lipoprotein related protein receptor 1 (LRP1), also known as CD91 or-
Macroglobulin-receptor, is a transmembrane receptor that interacts with more than 40 known …

Endogenous protease tissue-type plasminogen activator (tPA) has highly efficient fibrinolytic
activity and its recombinant variants alteplase and tenecteplase are established as highly …

Tissue plasminogen activator's (tPA) fibrinolytic function in the vasculature is well-
established. This specific role for tPA in the vasculature, however, contrasts with its …

The last two decades have witnessed a rapid decrease in mortality due to acute cerebral
ischemia that paradoxically has led to a rapid increase in the number of patients that survive …