Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery

D Vaudry, A Falluel-Morel, S Bourgault, M Basille… - Pharmacological …, 2009 - ASPET
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 38-amino acid C-terminally
α-amidated peptide that was first isolated 20 years ago from an ovine hypothalamic extract …

Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase‐activating polypeptide: IUPHAR review 1

AJ Harmar, J Fahrenkrug, I Gozes… - British journal of …, 2012 - Wiley Online Library
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase‐activating polypeptide
(PACAP) are members of a superfamily of structurally related peptide hormones that …

Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions

D Vaudry, BJ Gonzalez, M Basille, L Yon… - Pharmacological …, 2000 - ASPET
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 38-amino acid peptide that
was first isolated from ovine hypothalamic extracts on the basis of its ability to stimulate …

The origin and function of the pituitary adenylate cyclase-activating polypeptide (PACAP)/glucagon superfamily

NM Sherwood, SL Krueckl, JE McRory - Endocrine reviews, 2000 - academic.oup.com
The pituitary adenylate cyclase-activating polypeptide (PACAP)/glucagon superfamily
includes nine hormones in humans that are related by structure, distribution (especially the …

Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis

DJ Drucker - Molecular endocrinology, 2003 - academic.oup.com
Peptide hormones are secreted from endocrine cells and neurons and exert their actions
through activation of G protein-coupled receptors to regulate a diverse number of …

Discovery of PACAP and its receptors in the brain

T Hirabayashi, T Nakamachi, S Shioda - The journal of headache and pain, 2018 - Springer
Pituitary adenylate-cyclase-activating polypeptide (PACAP) is a 27-or 38-amino acid
neuropeptide, which belongs to the vasoactive intestinal polypeptide (VIP)/glucagon …

Cerebellar granule cells as a model to study mechanisms of neuronal apoptosis or survivalin vivo andin vitro

A Contestabile - The cerebellum, 2002 - Springer
Granule cells of the cerebellum constitute the largest homogeneous neuronal population of
mammalian brain. Due to their postnatal generation and the feasibility of well characterized …

Activation of Trk neurotrophin receptor signaling by pituitary adenylate cyclase-activating polypeptides

FS Lee, R Rajagopal, AH Kim, PC Chang… - Journal of Biological …, 2002 - ASBMB
Pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide that acts
through G protein-coupled receptors, exerts neuroprotective effects upon many neuronal …

Brain-derived neurotrophic factor mediates the anti-apoptotic effect of NMDA in cerebellar granule neurons: signal transduction cascades and site of ethanol action

SV Bhave, L Ghoda, PL Hoffman - Journal of Neuroscience, 1999 - Soc Neuroscience
Cerebellar granule neurons cultured in medium containing a physiological concentration of
KCl (5 mm) undergo apoptosis. The cells can be rescued by the in vitro addition of NMDA …

Multiple actions of pituitary adenylyl cyclase activating peptide in nervous system development and regeneration

JA Waschek - Developmental neuroscience, 2002 - karger.com
Pituitary adenylyl cyclase activating peptide (PACAP) is widely expressed in the embryonic
brain at the onset of neurogenesis, and is strongly upregulated in several models of nerve …