While drug toxicity (especially hepatotoxicity) is the most frequent reason cited for
withdrawal of an approved drug, no simple solution exists to adequately predict such …

The activities of the transaminases (aminotransferases) alanine aminotransferase and
aspartate aminotransferase in the blood (serum or plasma) are widely used as sensitive …

Brain is susceptible to oxidative stress and it is associated with age-related brain
dysfunction. Previously, we have pointed out a dramatic decrease of glutathione levels in the …

Featuring more than 4100 references, Drug-Induced Liver Disease is an invaluable
reference for gastroenterologists, hepatologists, family physicians, internists, pathologists …

Acetaminophen (APAP) overdose can induce acute liver injury (ALI) with significant
morbidity and mortality. Propacetamol is an APAP prodrug, which is clinically bioequivalent …

Serum activities of alanine and aspartate aminotransferases (ALT and AST) are used as
gold standard biomarkers for the diagnosis of hepatocellular injury. Since ALT and AST lack …

In a recent study in rats, alanine aminotransferase (ALT), the preferred plasma biomarker of
hepatocellular injury in rats, was ineffective at detecting marked hepatic necrosis produced …

Transport procedures usually cause fish stress. The purpose of this study was to investigate
the effect of transport stress on blood biochemical profiles, oxidative stress biomarkers, and …

Drug-induced liver injury (DILI) is a significant consideration for drug development. Current
preclinical DILI assessment relying on histopathology and clinical chemistry has limitations …

The increasing presence of pharmaceutical drugs in nature is cause of concern due to the
occurrence of oxidative stress in non-target species. Acetaminophen is widely used in …