Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease

Z Chen, R Tian, Z She, J Cai, H Li - Free Radical Biology and Medicine, 2020 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver
disease worldwide and is strongly associated with the presence of oxidative stress …

Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease

C Lebeaupin, D Vallée, Y Hazari, C Hetz, E Chevet… - Journal of …, 2018 - Elsevier
The global epidemic of obesity has been accompanied by a rising burden of non-alcoholic
fatty liver disease (NAFLD), with manifestations ranging from simple steatosis to non …

Oxidative stress is a key modulator in the development of nonalcoholic fatty liver disease

Y Ma, G Lee, SY Heo, YS Roh - Antioxidants, 2021 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide, and scientific studies consistently report that NAFLD development can be …

NAFLD and diabetes mellitus

H Tilg, AR Moschen, M Roden - Nature reviews Gastroenterology & …, 2017 - nature.com
The liver constitutes a key organ in systemic metabolism, contributing substantially to the
development of insulin resistance and type 2 diabetes mellitus (T2DM). The mechanisms …

Ischaemia reperfusion injury in liver transplantation: Cellular and molecular mechanisms

WA Dar, E Sullivan, JS Bynon, H Eltzschig… - Liver …, 2019 - Wiley Online Library
Liver disease causing end organ failure is a growing cause of mortality. In most cases, the
only therapy is liver transplantation. However, liver transplantation is a complex undertaking …

[HTML][HTML] Mitochondrial alterations in fatty liver diseases

B Fromenty, M Roden - Journal of hepatology, 2023 - Elsevier
Fatty liver diseases can result from common metabolic diseases, as well as from xenobiotic
exposure and excessive alcohol use, all of which have been shown to exert toxic effects on …

Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis

C Koliaki, J Szendroedi, K Kaul, T Jelenik, P Nowotny… - Cell metabolism, 2015 - cell.com
The association of hepatic mitochondrial function with insulin resistance and non-alcoholic
fatty liver (NAFL) or steatohepatitis (NASH) remains unclear. This study applied high …

Nonalcoholic fatty liver disease in adults: current concepts in etiology, outcomes, and management

T Marjot, A Moolla, JF Cobbold, L Hodson… - Endocrine …, 2020 - academic.oup.com
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of disease, extending from simple
steatosis to inflammation and fibrosis with a significant risk for the development of cirrhosis. It …

Glutathione and mitochondria

V Ribas, C García-Ruiz… - Frontiers in …, 2014 - frontiersin.org
Glutathione (GSH) is the main non-protein thiol in cells whose functions are dependent on
the redox-active thiol of its cysteine moiety that serves as a cofactor for a number of …

[HTML][HTML] Mitochondria in non-alcoholic fatty liver disease

ICM Simões, A Fontes, P Pinton, H Zischka… - The international journal …, 2018 - Elsevier
NAFLD is a common disease in Western society and ranges from steatosis to steatohepatitis
and to end-stage liver disease. The molecular mechanisms that cause the progression of …