A picture guide to cancer progression and monotonic accumulation models: evolutionary assumptions, plausible interpretations, and alternative uses
R Diaz-Uriarte - arXiv preprint arXiv:2312.06824, 2023 - arxiv.org
Cancer progression and monotonic accumulation models were developed to discover
dependencies in the irreversible acquisition of binary traits from cross-sectional data. They …
dependencies in the irreversible acquisition of binary traits from cross-sectional data. They …
Joint analysis of mutational and transcriptional landscapes in human cancer reveals key perturbations during cancer evolution
Background Tumors are able to acquire new capabilities, including traits such as drug
resistance and metastasis that are associated with unfavorable clinical outcomes. Single …
resistance and metastasis that are associated with unfavorable clinical outcomes. Single …
The temporal evolution of cancer hallmarks
Cancer hallmarks describe key physiological characteristics that distinguish cancers from
normal tissues. The temporal order in which these hallmarks appear during cancer …
normal tissues. The temporal order in which these hallmarks appear during cancer …
[PDF][PDF] Identification of Somatic Mutational Patterns with Biological and Clinical Significance in Solid and Hematological Malignancies
RE McNeil - 2024 - prism.ucalgary.ca
Cancers use Darwinian evolution to naturally select for advantageous DNA alterations that
allow these malignancies to escape normal biological control mechanisms. Advantageous …
allow these malignancies to escape normal biological control mechanisms. Advantageous …