Data-driven computational models of neurons, synapses, microcircuits, and mesocircuits
have become essential tools in modern brain research. The goal of these multiscale models …

Understanding the brain requires studying its multiscale interactions from molecules to
networks. The increasing availability of large-scale datasets detailing brain circuit …

Mutations in the SCN8A gene, encoding the voltage-gated sodium channel Na V 1.6, are
associated with a range of neurodevelopmental syndromes. The p.(Gly1625Arg)(G1625R) …

Most external stimuli, including sound, temperature, and illumination, exhibit spatially
heterogeneous, and different amplitudes of the same signal are received by neurons at …

Recent studies have found dramatic cell-type-specific responses to stimulus novelty,
highlighting the importance of analyzing the cortical circuitry at this granularity to understand …

The theory of the action potential was formulated by Hodgkin and Huxley 70 years ago. How
did the Hodgkin-Huxley model influence neuroscience since its publication in 1952? The …

The local field potential (LFP), the low-frequency part of the extracellular potential, reflects
transmembrane currents in the vicinity of the recording electrode. Thought mainly to stem …

Mutations in the SCN8A gene, encoding the voltage-gated sodium channel Nav1. 6, result in
a range of neurodevelopmental syndromes. The p.(Gly1625Arg)(G1625R) mutation was …

What does serotonin do? Just as the diffuse axonal arbours of midbrain serotonin neurons
touch nearly every corner of the forebrain, so too is this ancient neuromodulator involved in …

The human brain may be the most complicated thing in the discovered universe. Now is an
exciting time, when the capabilities of computing and neural recording technologies provide …