In the mammalian genome, DNA methylation is an epigenetic mechanism involving the
transfer of a methyl group onto the C5 position of the cytosine to form 5-methylcytosine. DNA …

The incidence of obesity and overweight has reached epidemic levels in the United States
and developed countries worldwide. Even more alarming is the increasing prevalence of …

As studies of DNA methylation increase in scope, it has become evident that methylation has
a complex relationship with gene expression, plays an important role in defining cell types …

DNA methylation has become increasingly recognized in the etiology of psychiatric
disorders. Because brain tissue is not accessible in living humans, epigenetic studies are …

Background Cardiovascular disease (CVD) is the leading cause of death worldwide and
considered one of the most environmentally driven diseases. The role of DNA methylation in …

We investigated whether ancestral liver damage leads to heritable reprogramming of
hepatic wound healing in male rats. We found that a history of liver damage corresponds …

Background The predominant model for regulation of gene expression through DNA
methylation is an inverse association in which increased methylation results in decreased …

Alzheimer's disease and other idiopathic dementias are associated with epigenetic
transformations. These transformations connect the environment and genes to …

Abstract We applied Illumina Human Methylation450K array to perform a genomic-scale
single-site resolution DNA methylation analysis in neuronal and nonneuronal (primarily …

Schizophrenia is a complex psychiatric disorder where genetic, epigenetic, and
environmental factors play a role in disease onset, course of illness, and treatment outcome …