Idiopathic pulmonary fibrosis

FJ Martinez, HR Collard, A Pardo, G Raghu… - Nature reviews Disease …, 2017 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease characterized by
progressive lung scarring and the histological picture of usual interstitial pneumonia (UIP). It …

The therapy of idiopathic pulmonary fibrosis: what is next?

V Somogyi, N Chaudhuri, SE Torrisi… - European …, 2019 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung
disease, characterised by progressive scarring of the lung and associated with a high …

An official American Thoracic Society/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial …

WD Travis, U Costabel, DM Hansell… - American journal of …, 2013 - atsjournals.org
Background: In 2002 the American Thoracic Society/European Respiratory Society
(ATS/ERS) classification of idiopathic interstitial pneumonias (IIPs) defined seven specific …

The role of immune and inflammatory cells in idiopathic pulmonary fibrosis

O Desai, J Winkler, M Minasyan, EL Herzog - Frontiers in medicine, 2018 - frontiersin.org
The contribution of the immune system to idiopathic pulmonary fibrosis (IPF) remains poorly
understood. While most sources agree that IPF does not result from a primary …

Clonal expansion of CD4+ cytotoxic T lymphocytes in patients with IgG4-related disease

H Mattoo, VS Mahajan, T Maehara… - Journal of Allergy and …, 2016 - Elsevier
Background IgG 4-related disease (IgG 4-RD) is a systemic condition of unknown cause
characterized by highly fibrotic lesions with dense lymphoplasmacytic infiltrates. CD4+ T …

Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis

T Maehara, N Kaneko, CA Perugino… - The Journal of …, 2020 - Am Soc Clin Investig
Systemic sclerosis (SSc) is an autoimmune fibrotic disease whose pathogenesis is poorly
understood and lacks effective therapies. We undertook quantitative analyses of T cell …

Revealing the pathogenic and aging-related mechanisms of the enigmatic idiopathic pulmonary fibrosis. an integral model

M Selman, A Pardo - American journal of respiratory and critical …, 2014 - atsjournals.org
A growing body of evidence indicates that aberrant activation of alveolar epithelial cells and
fibroblasts in an aging lung plays a critical role in the pathogenesis of idiopathic pulmonary …

Idiopathic pulmonary fibrosis

TE King, A Pardo, M Selman - The Lancet, 2011 - thelancet.com
Idiopathic pulmonary fibrosis is a devastating, age-related lung disease of unknown cause
that has few treatment options. This disease was once thought to be a chronic inflammatory …

Lung microbiome and disease progression in idiopathic pulmonary fibrosis: an analysis of the COMET study

MLK Han, Y Zhou, S Murray, N Tayob, I Noth… - The Lancet …, 2014 - thelancet.com
Background The role of the lung microbiome in the pathogenesis of idiopathic pulmonary
fibrosis is unknown. We investigated whether unique microbial signatures were associated …

Molecular and cellular mechanisms of pulmonary fibrosis

NW Todd, IG Luzina, SP Atamas - Fibrogenesis & tissue repair, 2012 - Springer
Pulmonary fibrosis is a chronic lung disease characterized by excessive accumulation of
extracellular matrix (ECM) and remodeling of the lung architecture. Idiopathic pulmonary …