New photosensitizers for photodynamic therapy
H Abrahamse, MR Hamblin - Biochemical Journal, 2016 - portlandpress.com
Photodynamic therapy (PDT) was discovered more than 100 years ago, and has since
become a well-studied therapy for cancer and various non-malignant diseases including …
become a well-studied therapy for cancer and various non-malignant diseases including …
[HTML][HTML] Mitostasis in neurons: maintaining mitochondria in an extended cellular architecture
T Misgeld, TL Schwarz - Neuron, 2017 - cell.com
Neurons have more extended and complex shapes than other cells and consequently face a
greater challenge in distributing and maintaining mitochondria throughout their arbors …
greater challenge in distributing and maintaining mitochondria throughout their arbors …
Blue-light receptors for optogenetics
Sensory photoreceptors underpin light-dependent adaptations of organismal physiology,
development, and behavior in nature. Adapted for optogenetics, sensory photoreceptors …
development, and behavior in nature. Adapted for optogenetics, sensory photoreceptors …
[HTML][HTML] Neuroendocrine coordination of mitochondrial stress signaling and proteostasis
During neurodegenerative disease, the toxic accumulation of aggregates and misfolded
proteins is often accompanied with widespread changes in peripheral metabolism, even in …
proteins is often accompanied with widespread changes in peripheral metabolism, even in …
Optogenetic activators of apoptosis, necroptosis, and pyroptosis
K Shkarina, E Hasel de Carvalho, JC Santos… - Journal of Cell …, 2022 - rupress.org
Targeted and specific induction of cell death in an individual or groups of cells hold the
potential for new insights into the response of tissues or organisms to different forms of …
potential for new insights into the response of tissues or organisms to different forms of …
C. elegans locomotion: small circuits, complex functions
M Zhen, ADT Samuel - Current opinion in neurobiology, 2015 - Elsevier
Highlights•The Caenorhabditis elegans motor circuit has a nearly complete connectome.•
Neurogenetic studies are unveiling a rich and complex set of signaling relationships …
Neurogenetic studies are unveiling a rich and complex set of signaling relationships …
Inducible and titratable silencing of Caenorhabditis elegans neurons in vivo with histamine-gated chloride channels
Recent progress in neuroscience has been facilitated by tools for neuronal activation and
inactivation that are orthogonal to endogenous signaling systems. We describe here a …
inactivation that are orthogonal to endogenous signaling systems. We describe here a …
[HTML][HTML] Mitophagy in the basolateral amygdala mediates increased anxiety induced by aversive social experience
K Duan, Q Gu, RS Petralia, YX Wang, D Panja, X Liu… - Neuron, 2021 - cell.com
Psychosocial stress is a common risk factor for anxiety disorders. The cellular mechanism for
the anxiogenic effect of psychosocial stress is largely unclear. Here, we show that chronic …
the anxiogenic effect of psychosocial stress is largely unclear. Here, we show that chronic …
A genetically targetable near-infrared photosensitizer
Upon illumination, photosensitizer molecules produce reactive oxygen species that can be
used for functional manipulation of living cells, including protein inactivation, targeted …
used for functional manipulation of living cells, including protein inactivation, targeted …
[HTML][HTML] All-optical spatiotemporal mapping of ROS dynamics across mitochondrial microdomains in situ
Abstract Hydrogen peroxide (H2O2) functions as a second messenger to signal metabolic
distress through highly compartmentalized production in mitochondria. The dynamics of …
distress through highly compartmentalized production in mitochondria. The dynamics of …