Ribosome-associated quality-control (RQC) surveys incomplete nascent polypeptides
produced by interrupted translation. Central players in RQC are the human ribosome-and …

The stalling of ribosomes during protein synthesis results in the production of truncated
polypeptides that can have deleterious effects on cells and therefore must be eliminated. In …

Ubiquitylation is an essential posttranslational modification that controls cell division,
differentiation, and survival in all eukaryotes. By combining multiple E3 ligases (writers) …

Protein synthesis by the ribosome can fail for numerous reasons including faulty mRNA,
insufficient availability of charged tRNAs and genetic errors. All organisms have evolved …

Translation arrest by polybasic sequences induces ribosome stalling, and the arrest product
is degraded by the ribosome-mediated quality control (RQC) system. Here we report that …

Diverse cellular stressors have been observed to trigger site-specific ubiquitination on
several ribosomal proteins. However, the ubiquitin ligases, biochemical consequences, and …

Translating ribosomes that slow excessively incur collisions with trailing ribosomes.
Persistent collisions are detected by ZNF598, a ubiquitin ligase that ubiquitinates sites on …

Translation of messenger RNAs lacking a stop codon results in the addition of a carboxy-
terminal poly-lysine tract to the nascent polypeptide, causing ribosome stalling. Non-stop …

Ribosome-associated quality control (RQC) represents a rescue pathway in eukaryotic cells
that is triggered upon translational stalling. Collided ribosomes are recognized for …

Cells of all organisms survey problems during translation elongation, which may happen as
a consequence of mRNA aberrations, inefficient decoding, or other sources. In eukaryotes …