Malaria during pregnancy

M Fried, PE Duffy - Cold Spring Harbor …, 2017 - perspectivesinmedicine.cshlp.org
One hundred and twenty-five million women in malaria-endemic areas become pregnant
each year (see Dellicour et al. PLoS Med 7: e1000221 [2010]) and require protection from …

Functional antibodies and protection against blood-stage malaria

A Teo, G Feng, GV Brown, JG Beeson… - Trends in …, 2016 - cell.com
Numerous efforts to understand the functional roles of antibodies demonstrated that they can
protect against malaria. However, it is unclear which antibody responses are the best …

First-in-human, randomized, double-blind clinical trial of differentially adjuvanted PAMVAC, a vaccine candidate to prevent pregnancy-associated malaria

B Mordmüller, M Sulyok, D Egger-Adam… - Clinical Infectious …, 2019 - academic.oup.com
Background Malaria in pregnancy has major impacts on mother and child health. To
complement existing interventions, such as intermittent preventive treatment and use of …

Progress and insights toward an effective placental malaria vaccine

B Gamain, A Chêne, NK Viebig… - Frontiers in …, 2021 - frontiersin.org
In areas where Plasmodium falciparum transmission is endemic, clinical immunity against
malaria is progressively acquired during childhood and adults are usually protected against …

Plasmodium falciparum Blood Stage Antimalarial Vaccines: An Analysis of Ongoing Clinical Trials and New Perspectives Related to Synthetic Vaccines

DR Salamanca, M Gómez, A Camargo… - Frontiers in …, 2019 - frontiersin.org
Plasmodium falciparum malaria is a disease causing high morbidity and mortality rates
worldwide, mainly in sub-Saharan Africa. Candidates have been identified for vaccines …

The molecular mechanism of cytoadherence to placental or tumor cells through VAR2CSA from Plasmodium falciparum

W Wang, Z Wang, X Yang, Y Gao, X Zhang, L Cao… - Cell discovery, 2021 - nature.com
Dear Editor, Pregnancy-associated malaria (PAM) threatened more than one million women
and their infants in endemic regions in 2019. This resulted in maternal anemia, stillbirth, and …

Placental Malaria: Decreased Transfer of Maternal Antibodies Directed to Plasmodium falciparum and Impact on the Incidence of Febrile Infections in Infants

C Dechavanne, G Cottrell, A Garcia, F Migot-Nabias - PloS one, 2015 - journals.plos.org
The efficacy of mother-to-child placental transfer of antibodies specific to malaria blood
stage antigens was investigated in the context of placental malaria infection, taking into …

Preclinical immunogenicity and safety of the cGMP-grade placental malaria vaccine PRIMVAC

A Chêne, S Gangnard, A Guadall, H Ginisty, O Leroy… - …, 2019 - thelancet.com
Background VAR2CSA is the lead antigen for developing a vaccine that would protect
pregnant women against placental malaria. A multi-system feasibility study has identified E …

Clinical development of placental malaria vaccines and immunoassays harmonization: a workshop report

A Chêne, S Houard, MA Nielsen, S Hundt, F D'Alessio… - 2016 - Springer
Placental malaria caused by Plasmodium falciparum infection constitutes a major health
problem manifesting as severe disease and anaemia in the mother, impaired fetal …

Progress and new horizons toward a VAR2CSA-based placental malaria vaccine

JYA Doritchamou, J Suurbaar… - Expert Review of …, 2021 - Taylor & Francis
Introduction: Several malaria vaccines are under various phases of development with some
promising results. In placental malaria (PM) a deliberately anti-disease approach is …