The capacity for cancer cells to metastasize to distant organs depends on their ability to
execute the carefully choreographed processes of cell adhesion and migration. As most …

Abstract Design of tubulin inhibitors as anticancer drugs dynamically developed over the
past 20 years. The modern arsenal of potential tubulin-targeting anticancer agents is …

Microtubule-targeting agents (MTAs) are effective drugs for cancer treatment. A novel diaryl
[1, 2] oxazole class of compounds binding the colchicine site was synthesized as cis …

Novel N-benzylarylamide saderivatives were designed and synthesized, and their
antiproliferative activities were explored. Some of 51 target compounds exhibited potent …

Uncontrolled inflammation predisposes to pleiotropic effects leading to cancer development
thanks to promoting all stages of tumorigenesis. Therefore, cancer-associated inflammation …

Ewing sarcoma (EWS) is a pediatric malignancy driven by the EWSR1-FLI1 fusion protein
formed by the chromosomal translocation t (11; 22). The small molecule TK216 was …

Extensive preclinical studies have shown that colchicine-binding site inhibitors (CBSIs) are
promising drug candidates for cancer therapy. Although numerous CBSIs were generated …

Cryptoconcatones AL represent a series of 12 dihydropyrone derivatives isolated from the
evergreen tree Cryptocarya concinna Hance, which is well distributed in southeast Asia. The …

Given the essential role of Epigenetic regulation in many biological processes, targeted
epigenetic drugs have been gradually applied to the treatment of tumors. Histone …

Colorectal cancer (CRC) is a common malignancy of the gastrointestinal tract with high
morbidity and mortality. Our previous studies have demonstrated that indole-chalcone …