The landmark discoveries of leptin and adiponectin firmly established adipose tissue as a
sophisticated and highly active endocrine organ, opening a new era of investigating adipose …

Adiponectin is the most abundant peptide secreted by adipocytes, whose reduction plays a
central role in obesity-related diseases, including insulin resistance/type 2 diabetes and …

Adipose tissue regulates numerous physiological processes, and its dysfunction in obese
humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 …

Obesity is causally linked with the development of cardiovascular disorders. Accumulating
evidence indicates that cardiovascular disease is the collateral damage of obesity-driven …

Adiponectin is an adipocyte-specific factor, first described in 1995. Over the past two
decades, numerous studies have elucidated the physiological functions of adiponectin in …

There has been an upsurge of interest in the adipocyte coincident with the onset of the
obesity epidemic and the realization that adipose tissue plays a major role in the regulation …

Obesity-linked type 2 diabetes is one of the paramount causes of morbidity and mortality
worldwide, posing a major threat on human health, productivity, and quality of life. Despite …

VE-cadherin is a component of endothelial cell-to-cell adherens junctions, and it has a key
role in the maintenance of vascular integrity. During embryo development, VE-cadherin is …

The worldwide epidemic of obesity has brought considerable attention to research aimed at
understanding the biology of adipocytes (fat cells) and the events occurring in adipose …

Obesity is a risk factor for various cardiovascular diseases including hypertension,
atherosclerosis, and myocardial infarction. Recent studies aimed at understanding the …