Despite rapid advances in modern medical technology and significant improvements in
survival rates of many cancers, pancreatic cancer is still a highly lethal gastrointestinal …

Cell proliferation, apoptosis, autophagy, oxidative stress and metabolic dysregulation are
the basis of many diseases. Forkhead box transcription factor O1 (FOXO1) changes in …

Research on obesity-and diabetes mellitus (DM)-related carcinogenesis has expanded
exponentially since these two diseases were recognized as important risk factors for …

The most frequent pancreatic cancer is pancreatic adenocarcinoma. It has high and early
locally and distant invasiveness; this is the reason why it often shows little sign or symptoms …

Background Pancreatic cancer (PC) is among foremost causes of cancer related deaths
worldwide due to generic symptoms, lack of effective screening strategies and resistance to …

Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest types of cancer. The
worldwide estimates of its incidence and mortality in the general population are eight cases …

Pancreatic cancer is one of the leading determinants of global cancer mortality, and its
incidence is predicted to increase, to become in 2030 the second most common cause of …

Fibrosis is a universally age-related disease that involves nearly all organs. It is typically
initiated by organic injury and eventually results in organ failure. There are still few effective …

Pancreatic ductal adenocarcinoma (PDAC) is unrivalled the deadliest gastrointestinal
cancer in the western world. There is substantial evidence implying that insulin and insulin …

Cells in different tissues, including endocrine cells in the pancreas, live in complex
microenvironments that are rich in cellular and acellular components. Intricate interactions …