Nanozyme for tumor therapy: Surface modification matters

G Tang, J He, J Liu, X Yan, K Fan - Exploration, 2021 - Wiley Online Library
As the next generation of artificial enzymes, nanozymes have shown unique properties
compared to its natural counterparts, such as stability in harsh environment, low cost, and …

Metal-organic frameworks with different dimensionalities: An ideal host platform for enzyme@ MOF composites

Y Du, X Jia, L Zhong, Y Jiao, Z Zhang, Z Wang… - Coordination Chemistry …, 2022 - Elsevier
Metal-organic frameworks (MOFs) are an emerging class of porous materials with well-
defined pore and crystal structure, favorable biocompatibility, good chemo-/machinal …

Recent advances on endogenous/exogenous stimuli-triggered nanoplatforms for enhanced chemodynamic therapy

Q Sun, Z Wang, B Liu, F He, S Gai, P Yang… - Coordination Chemistry …, 2022 - Elsevier
In view of certain unique internalization features of the tumor microenvironment
(TME)(mainly including hypoxia, acidity and higher concentrations of H 2 O 2 and GSH) …

Engineering Single-Atom Iron Nanozymes with Radiation-Enhanced Self-Cascade Catalysis and Self-Supplied H2O2 for Radio-enzymatic Therapy

X Zhu, J Wu, R Liu, H Xiang, W Zhang, Q Chang… - ACS …, 2022 - ACS Publications
Single-atom nanozymes (SAzymes), with individually isolated metal atom as active sites,
have shown tremendous potential as enzyme-based drugs for enzymatic therapy. However …

Recent advances in Zn-MOFs and their derivatives for cancer therapeutic applications

M Li, Z Zhang, Y Yu, H Yuan… - Materials …, 2023 - pubs.rsc.org
Researchers have developed dozens of cancer treatment strategies to address the high
proportion of cancer deaths in total deaths. However, the treatment of cancer inevitably has …

Bifunctional cascading nanozymes based on carbon dots promotes photodynamic therapy by regulating hypoxia and glycolysis

T Luo, H Yang, R Wang, Y Pu, Z Cai, Y Zhao, Q Bi… - ACS …, 2023 - ACS Publications
Photodynamic therapy (PDT) still faces great challenges with suitable photosensitizers,
oxygen supply, and reactive oxygen species (ROS) accumulation, especially in the tumor …

Exploration of nanozymes in viral diagnosis and therapy

J Lee, H Liao, Q Wang, J Han, JH Han, HE Shin… - …, 2022 - Wiley Online Library
Nanozymes are nanomaterials with similar catalytic activities to natural enzymes. Compared
with natural enzymes, they have numerous advantages, including higher physiochemical …

Nanozyme-involved biomimetic cascade catalysis for biomedical applications

X Cai, L Jiao, H Yan, Y Wu, W Gu, D Du, Y Lin, C Zhu - Materials Today, 2021 - Elsevier
Enzyme cascade reactions in biological systems can effectively improve the catalytic
performances owing to their high local concentration, efficient mass transfer and reduced …

Enzyme mimics for engineered biomimetic cascade nanoreactors: mechanism, applications, and prospects

X Zhang, G Li, G Chen, D Wu, Y Wu… - Advanced Functional …, 2021 - Wiley Online Library
Multiple enzyme‐driven biological catalytic cascades occur in living organisms, guiding
highly efficient and selective transformations of substrates. Inspired by the merits of these …

DNAzyme‐Mediated Cascade Nanoreactor for Cuproptosis‐Promoted Pancreatic Cancer Synergistic Therapy

Q Yu, J Zhou, Y Liu, XQ Li, S Li, H Zhou… - Advanced …, 2023 - Wiley Online Library
Cuproptosis, a kind of newly recognized cell death modality, shows enormous prospect in
cancer treatment. The inducer of cuproptosis has more advantages in tumor therapy …