A review on anticancer potential of bioactive heterocycle quinoline

O Afzal, S Kumar, MR Haider, MR Ali, R Kumar… - European Journal of …, 2015 - Elsevier
The advent of Camptothecin added a new dimension in the field anticancer drug
development containing quinoline motif. Quinoline scaffold plays an important role in …

Quinoline as a privileged scaffold in cancer drug discovery

VR Solomon, H Lee - Current medicinal chemistry, 2011 - ingentaconnect.com
Quinoline (1-azanaphthalene) is a heterocyclic aromatic nitrogen compound characterized
by a double-ring structure that contains a benzene ring fused to pyridine at two adjacent …

Biocide effects of volatile organic compounds produced by potential biocontrol rhizobacteria on Sclerotinia sclerotiorum

A Giorgio, A De Stradis, P Lo Cantore… - Frontiers in …, 2015 - frontiersin.org
Six rhizobacteria isolated from common bean and able to protect bean plants from the
common bacterial blight (CBB) causal agent, were in vitro evaluated for their potential …

Synthesis, characterization and anti-cancer activity of hydrazide derivatives incorporating a quinoline moiety

M Bingul, O Tan, CR Gardner, SK Sutton, GM Arndt… - Molecules, 2016 - mdpi.com
Identification of the novel (E)-N′-((2-chloro-7-methoxyquinolin-3-yl) methylene)-3-
(phenylthio) propanehydrazide scaffold 18 has led to the development of a new series of …

Ambident reactivity of phenolate anions revisited: a quantitative approach to phenolate reactivities

RJ Mayer, M Breugst, N Hampel… - The Journal of Organic …, 2019 - ACS Publications
Prompted by the observation that the regioselectivities of phenolate reactions (C versus O
attack) are opposite to the predictions by the principle of hard and soft acids and bases, we …

Recent advances in the synthesis and biological activity of 8-hydroxyquinolines

HA Saadeh, KA Sweidan, MS Mubarak - Molecules, 2020 - mdpi.com
Compounds containing the 8-hydroxyquinoline (8-HQ) 1 nucleus exhibit a wide range of
biological activities, including antimicrobial, anticancer, and antifungal effects. The chemistry …

DNA targeting half sandwich Ru (II)-p-cymene-N^ N complexes as cancer cell imaging and terminating agents: Influence of regioisomers in cytotoxicity

A Mondal, U Sen, N Roy, V Muthukumar… - Dalton …, 2021 - pubs.rsc.org
For diagnosing and annihilating cancer in the human body, herein, we have adopted a one
pot convenient synthetic protocol to synthesize a library of half sandwich Ru (II)-p-cymene …

One-step catalytic synthesis of alkyl-substituted quinolines

CE Meyet, CH Larsen - The Journal of Organic Chemistry, 2014 - ACS Publications
Difficult-to-access alkyl-substituted quinolines are formed directly from commercially
available anilines, aldehydes, and alkynes bearing a variety of substituents. Copper (II) …

Synthesis and antiviral activity of substituted quercetins

M Thapa, Y Kim, J Desper, KO Chang… - Bioorganic & medicinal …, 2012 - Elsevier
Influenza viruses are important pathogens that cause respiratory infections in humans and
animals. In addition to vaccination, antiviral drugs against influenza virus play a significant …

Antimalarial activity of novel 5-aryl-8-aminoquinoline derivatives

H Shiraki, MP Kozar, V Melendez… - Journal of medicinal …, 2011 - ACS Publications
In an attempt to separate the antimalarial activity of tafenoquine (3) from its hemolytic side
effects in glucose-6-phosphate dehydrogenase (G6PD) deficiency patients, a series of 5-aryl …