Objective Mitochondria are multifunctional life-sustaining organelles that represent a
potential intersection point between psychosocial experiences and biological stress …

There is growing scientific interest to develop scalable biological measures that capture
mitochondrial (dys) function. Mitochondria have their own genome, the mitochondrial DNA …

Respirometry is the gold standard measurement of mitochondrial oxidative function, as it
reflects the activity of the electron transport chain complexes working together. However, the …

Essentials• The metabolic integration processes required for platelet activation are unclear.•
The metabolic plasticity of human platelets were investigated.• Activated platelets exhibit a …

Platelet thrombus formation includes several integrated processes involving aggregation,
secretion of granules, release of arachidonic acid and clot retraction, but it is not clear which …

The immunometabolic mechanisms underlying suboptimal T cell immunity in tuberculosis
remain undefined. Here, we examine how chronic Mycobacterium tuberculosis (Mtb) and M …

Oxalate is a small compound found in certain plant-derived foods and is a major component
of calcium oxalate (CaOx) kidney stones. Individuals that consume oxalate enriched meals …

The platelet is considered as an accessible and valuable tool to study mitochondrial
function, owing to its greater content of fully functional mitochondria compared with other …

Numerous studies show that mitochondrial energy generation determines the effectiveness
of immune responses. Furthermore, changes in mitochondrial function may regulate …

Mitochondria operate as hubs of cellular metabolism that execute important regulatory
functions. Damaged/dysfunctional mitochondria are recognized as major pathogenic …