Red blood cells: Supercarriers for drugs, biologicals, and nanoparticles and inspiration for advanced delivery systems

CH Villa, AC Anselmo, S Mitragotri… - Advanced drug delivery …, 2016 - Elsevier
Red blood cells (RBCs) constitute a unique drug delivery system as a biologic or hybrid
carrier capable of greatly enhancing pharmacokinetics, altering pharmacodynamics (for …

Role of monosaccharide transport proteins in carbohydrate assimilation, distribution, metabolism, and homeostasis

AJ Cura, A Carruthers - Comprehensive Physiology, 2011 - Wiley Online Library
The facilitated diffusion of glucose, galactose, fructose, urate, myoinositol, and
dehydroascorbic acid in mammals is catalyzed by a family of 14 monosaccharide transport …

Microneedle patches loaded with nanovesicles for glucose transporter-mediated insulin delivery

Q Chen, Z Xiao, C Wang, G Chen, Y Zhang, X Zhang… - ACS …, 2022 - ACS Publications
Glucose-responsive insulin delivery systems that mimic insulin secretion activity in the
pancreas show great potential to improve clinical therapeutic outcomes for people with type …

[HTML][HTML] Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification

L Oburoglu, S Tardito, V Fritz, SC De Barros, P Merida… - Cell stem cell, 2014 - cell.com
The metabolic state of quiescent hematopoietic stem cells (HSCs) is an important regulator
of self-renewal, but it is unclear whether or how metabolic parameters contribute to HSC …

Red blood cells for glucose‐responsive insulin delivery

C Wang, Y Ye, W Sun, J Yu, J Wang… - Advanced …, 2017 - Wiley Online Library
Glucose‐responsive delivery of insulin mimicking the function of pancreatic β‐cells to
achieve meticulous control of blood glucose (BG) would revolutionize diabetes care. Here …

[HTML][HTML] Myths, artifacts, and fatal flaws: identifying limitations and opportunities in vitamin C research

AJ Michels, B Frei - Nutrients, 2013 - mdpi.com
Research progress to understand the role of vitamin C (ascorbic acid) in human health has
been slow in coming. This is predominantly the result of several flawed approaches to study …

[HTML][HTML] Low red blood cell vitamin C concentrations induce red blood cell fragility: a link to diabetes via glucose, glucose transporters, and dehydroascorbic acid

H Tu, H Li, Y Wang, M Niyyati, Y Wang, J Leshin… - …, 2015 - thelancet.com
Strategies to prevent diabetic microvascular angiopathy focus on the vascular endothelium.
Because red blood cells (RBCs) are less deformable in diabetes, we explored an original …

Anemia and transfusion in the neonate

R Colombatti, L Sainati, D Trevisanuto - Seminars in Fetal and Neonatal …, 2016 - Elsevier
Neonatal anemia is a frequent occurrence in neonatal intensive care units. Red blood cell
transfusion criteria in case of blood loss are clearly defined but optimal hemoglobin or …

Metabolic regulation of hematopoietic stem cell commitment and erythroid differentiation

L Oburoglu, M Romano, N Taylor… - Current Opinion in …, 2016 - journals.lww.com
Metabolic regulation of hematopoietic stem cell commitment a... : Current Opinion in
Hematology Metabolic regulation of hematopoietic stem cell commitment and erythroid …

[HTML][HTML] An IDH1-vitamin C crosstalk drives human erythroid development by inhibiting pro-oxidant mitochondrial metabolism

P Gonzalez-Menendez, M Romano, H Yan… - Cell reports, 2021 - cell.com
The metabolic changes controlling the stepwise differentiation of hematopoietic stem and
progenitor cells (HSPCs) to mature erythrocytes are poorly understood. Here, we show that …