The MYC protooncogene functions as a universal amplifier of transcription through
interaction with numerous factors and complexes that regulate almost every cellular process …

Dysregulated expression of the transcription factor MYCN is frequently detected in nervous
system tumors such as childhood neuroblastoma. Here, gene amplification of MYCN is a …

Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to
originate from undifferentiated neural crest cells. Amplification of the MYC family member …

The pathophysiological roles and the therapeutic potentials of Myc family are reviewed in
this article. The physiological functions and molecular machineries in stem cells, including …

Enhanced and deregulated expression of N-MYC, a member of the MYC family of
transcription factors, drives the development of multiple tumors, including tumors of the …

Despite its obvious importance, physical insight into the origins of hydrophobicity is not easy
to come by. Thermodynamic measurements are one approach, but interpreting their physical …

▪ Abstract The Myc/Max/Mad network comprises a group of transcription factors whose
distinct interactions result in gene-specific transcriptional activation or repression. A great …

Abstract c-myc, N-myc and L-myc are the three members of the myc oncoprotein family
whose role in the pathogenesis of many human neoplastic diseases has received wide …

THE kidney has been widely exploited as a model system for the study of tissue inductions
regulating vertebrate organogenesis1, 2. Kidney development is initiated by the ingrowth of …

Murine ES cells can be maintained as a pluripotent, self-renewing population by LIF/STAT3-
dependent signaling. The downstream effectors of this pathway have not been previously …