A State of the Art lecture titled “Blood Clot Contraction: Mechanisms, Pathophysiology, and
Disease” was presented at the International Society on Thrombosis and Haemostasis (ISTH) …

Following the advent of mechanical thrombectomy, occlusive clots in ischemic stroke have
been amply characterized using conventional histopathology. Many studies have …

While blood clot formation has been relatively well studied, little is known about the
mechanisms underlying the subsequent structural and mechanical clot remodeling called …

Ischaemic stroke is a major cause of morbidity and mortality worldwide. Blood clotting and
thromboembolism play a central role in the pathogenesis of ischaemic stroke. An increasing …

Thrombosis, resulting in occlusive blood clots, blocks blood flow to downstream organs and
causes life-threatening conditions such as heart attacks and strokes. The administration of …

Background Piezo1 is a mechanosensitive cationic channel that boosts intracellular [Ca 2+]
i. Compression of red blood cells (RBCs) during platelet-driven contraction of blood clots …

Autoimmune diseases, including systemic lupus erythematosus (SLE), have a high risk of
thrombotic and hemorrhagic complications associated with altered platelet functionality. We …

Portal vein thrombosis (PVT) is a challenging and controversial complication of cirrhosis.
Experimental models that reproduce cirrhotic PVT and effective pharmacological therapies …

Nonmuscle cell contractility is an essential feature underlying diverse cellular processes
such as motility, morphogenesis, division and genome replication, intracellular transport …

Contraction of blood clots plays an important role in blood clotting, a natural process that
restores hemostasis and regulates thrombosis in the body. Upon injury, a chain of events …