Cancer cells are well documented to rewire their metabolism and energy production
networks to support and enable rapid proliferation, continuous growth, survival in harsh …

Localized proton magnetic resonance spectroscopy (MRS) of the human brain, first reported
more than 20 years ago, 1–3 is a mature methodology that is used clinically in many medical …

The use of magnetic resonance imaging (MRI) in radiotherapy (RT) planning is rapidly
expanding. We review the wide range of image contrast mechanisms available to MRI and …

A major challenge in cancer biology is to monitor and understand cancer metabolism in vivo
with the goal of improved diagnosis and perhaps therapy. Because of the complexity of …

In this work we demonstrate that specific MR image contrast can be produced in the water
signal that reflects endogenous cellular protein and peptide content in intracranial rat 9L …

This paper presents a review of imaging techniques and of their utility in system biology.
During the last decade systems biology has matured into a distinct field and imaging has …

Dynamic nuclear polarization is an emerging technique for increasing the sensitivity of
magnetic resonance imaging and spectroscopy, particularly for low‐γ nuclei. The technique …

The clinical use of in vivo magnetic resonance spectroscopy (MRS) has been limited for a
long time, mainly due to its low sensitivity. However, with the advent of clinical MR systems …

Purpose To investigate the feasibility of a three‐dimensional amide‐proton‐transfer (APT)
imaging sequence with gradient‐and spin‐echo readouts at 3 Tesla in patients with high‐or …

Accurate diagnosis is essential for optimum management and treatment of patients with
brain tumours. Proton magnetic resonance spectroscopy (1H MRS) provides information …