[HTML][HTML] Pancreatic β-cell dysfunction in type 2 diabetes: Implications of inflammation and oxidative stress
PV Dludla, SE Mabhida, K Ziqubu… - World journal of …, 2023 - ncbi.nlm.nih.gov
Insulin resistance and pancreatic β-cell dysfunction are major pathological mechanisms
implicated in the development and progression of type 2 diabetes (T2D). Beyond the …
implicated in the development and progression of type 2 diabetes (T2D). Beyond the …
Revisiting the antigen-presenting function of β cells in T1D pathogenesis
Y Li, F Sun, TT Yue, FX Wang, CL Yang… - Frontiers in …, 2021 - frontiersin.org
Type 1 diabetes (T1D) is characterized by the unresolved autoimmune inflammation and
islet β cell destruction. The islet resident antigen-presenting cells (APCs) including dendritic …
islet β cell destruction. The islet resident antigen-presenting cells (APCs) including dendritic …
Antidiabetic efficacy of lactoferrin in type 2 diabetic pediatrics; controlling impact on PPAR-γ, SIRT-1, and TLR4 downstream signaling pathway
WA Mohamed, MF Schaalan - Diabetology & metabolic syndrome, 2018 - Springer
The current study aims to investigate the antidiabetic efficacy of camel milk-derived
lactoferrin and potential involvement of PPAR-γ and SIRT-1 via TLR-4/NFκB signaling …
lactoferrin and potential involvement of PPAR-γ and SIRT-1 via TLR-4/NFκB signaling …
IL-6 is present in beta and alpha cells in human pancreatic islets: Expression is reduced in subjects with type 1 diabetes
S Rajendran, F Anquetil, E Quesada-Masachs… - Clinical …, 2020 - Elsevier
IL-6 is a pro-inflammatory cytokine upregulated in some autoimmune diseases. The role of
IL-6 in the development of type 1 diabetes (T1D) is unclear. Clinical studies are investigating …
IL-6 in the development of type 1 diabetes (T1D) is unclear. Clinical studies are investigating …
Aquaporin-7 and aquaporin-12 modulate the inflammatory phenotype of endocrine pancreatic beta-cells
IV da Silva, C Cardoso, L Méndez-Giménez… - Archives of biochemistry …, 2020 - Elsevier
Aquaporins (AQPs) facilitate water and glycerol movement across membranes. AQP7 is the
main aquaglyceroporin in pancreatic β-cells and was proposed to play a role in insulin …
main aquaglyceroporin in pancreatic β-cells and was proposed to play a role in insulin …
Fetuin-A secretion from β-cells leads to accumulation of macrophages in islets, aggravates inflammation and impairs insulin secretion
Elevated fetuin-A levels, chemokines and islet-resident macrophages are crucial factors
associated with obesity-mediated type 2 diabetes (T2D). Here, the aim of the study was to …
associated with obesity-mediated type 2 diabetes (T2D). Here, the aim of the study was to …
Sitagliptin favorably modulates immune-relevant pathways in human beta cells
Abstract Type 2 diabetes (T2D) is a condition characterized by hyperglycemia and chronic
complications. Antidiabetic drugs and lifestyle interventions are the current gold standard …
complications. Antidiabetic drugs and lifestyle interventions are the current gold standard …
Clinical recommendations for the use of islet cell autoantibodies to distinguish autoimmune and non-autoimmune gestational diabetes
K Haller-Kikkatalo, R Uibo - Clinical reviews in allergy & immunology, 2016 - Springer
Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance that begins or is
first recognized during pregnancy. The prevalence of GDM is highly variable, depending on …
first recognized during pregnancy. The prevalence of GDM is highly variable, depending on …
Significance of interleukin-6/STAT pathway for the gene expression of REG Iα, a new autoantigen in Sjögren's syndrome patients, in salivary duct epithelial cells
T Fujimura, T Fujimoto, A Itaya-Hironaka… - Clinical Reviews in …, 2017 - Springer
The regenerating gene, Reg, was originally isolated from a rat regenerating islet
complementary DNA (cDNA) library, and its human homologue was named REG Iα …
complementary DNA (cDNA) library, and its human homologue was named REG Iα …
Mast cells contribute to autoimmune diabetes by releasing interleukin-6 and failing to acquire a tolerogenic IL-10+ phenotype
Mast cells (MCs) are innate immune cells that exert positive and negative immune
modulatory functions capable to enhance or limit the intensity and/or duration of adaptive …
modulatory functions capable to enhance or limit the intensity and/or duration of adaptive …