Immunotherapy strategies against cancer are emerging as powerful weapons for treatment
of this disease. The success of checkpoint inhibitors against metastatic melanoma and …

The presence of inflammatory immune cells in human tumors raises a fundamental question
in oncology: How do cancer cells avoid the destruction by immune attack? In principle, tumor …

Regulatory T (Treg) cells reside in lymphoid organs and barrier tissues where they control
different types of inflammatory responses. Treg cells are also found in human cancers, and …

Background: Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX)
Syndrome is a rare recessive disorder caused by mutations in the FOXP3 gene. In addition …

Regulatory T cells (Tregs) are engaged in maintaining immune homeostasis and preventing
autoimmunity. Treg cells include thymic Treg cells and peripheral Treg cells, both of which …

Recent evidence shows that when ischemic stroke (IS) occurs, the BBB would be destructed,
thereby promoting the immune cells to migrate into the brain, suggesting that the immune …

Regulatory T (Treg) cells are essential for maintaining peripheral tolerance, preventing
autoimmunity, and limiting chronic inflammatory diseases. This small CD4+ T cell population …

The outbreak of coronavirus disease 2019 (COVID-19) is caused by the infection of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which leads to the disruption of …

Lung cancer is a leading cause of cancer-related deaths worldwide. Lung cancer risk
factors, including smoking and exposure to environmental carcinogens, have been linked to …

Regulatory T cells (Tregs) can exert their functions through multiple suppressive
mechanisms; however, it is unclear how Tregs exactly employ these mechanisms. In this …