Nature has developed a plethora of protein machinery to operate and maintain nearly every
task of cellular life. These processes are tightly regulated via post‐expression modifications …

Despite significant progress in clinical management, drug resistance remains a major
obstacle. Recent research based on protein degradation to restrain drug resistance has …

Ubiquitin (Ub) chain formation by homologous to E6AP C-terminus (HECT)-family E3 ligases
regulates vast biology, yet the structural mechanisms remain unknown. We used chemistry …

All eukaryotes require intricate protein networks to translate developmental signals into
accurate cell fate decisions. Mutations that disturb interactions between network …

Targeted protein degradation is a groundbreaking modality in drug discovery; however, the
regulatory mechanisms are still not fully understood. Here, we identify cellular signaling …

Abstract Histone deacetylase 6 (HDAC6) mediates DNA damage signaling by regulating the
mismatch repair and nucleotide excision repair pathways. Whether HDAC6 also mediates …

Ferroptosis, an iron‐dependent form of regulated cell death driven by excessive
accumulation of lipid peroxides, has become a promising strategy in cancer treatment …

HUWE1 is a large, enigmatic HECT-domain ubiquitin ligase implicated in the regulation of
diverse pathways, including DNA repair, apoptosis, and differentiation. How HUWE1 …

Ferroptosis is an iron-dependent type of regulated cell death resulting from extensive lipid
peroxidation and plays a critical role in various physiological and pathological processes …

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection. The inflammatory cytokine storm causes systemic organ damage, especially acute …