Tuberculosis (TB) is among the most difficult infections to treat, requiring several months of
multidrug therapy to produce a durable cure. The reasons necessitating long treatment times …

Mycobacterium tuberculosis (Mtb) infection is notoriously difficult to treat. Treatment efficacy
is limited by Mtb's intrinsic drug resistance, as well as its ability to evolve acquired resistance …

Transmission-driven multi-/extensively drug resistant (M/XDR) tuberculosis (TB) is the
largest single contributor to human mortality due to antimicrobial resistance. A few major …

In the face of the unrelenting global burden of tuberculosis (TB), antibiotics remain our most
effective tools to save lives and control the spread of Mycobacterium tuberculosis (Mtb) …

Page 1 Catalogue of mutations in Mycobacterium tuberculosis complex and their
association with drug resistance Second edition Page 2 Page 3 Catalogue of mutations in …

The widespread use of antibiotics has placed bacterial pathogens under intense pressure to
evolve new survival mechanisms. Genomic analysis of 51,229 Mycobacterium tuberculosis …

Gene regulatory networks allow organisms to generate coordinated responses to
environmental challenges. In bacteria, regulatory networks are re-wired and re-purposed …

Despite the existence of well-characterized, canonical mutations that confer high-level drug
resistance to Mycobacterium tuberculosis (Mtb), there is evidence that drug resistance …

Tuberculosis, caused by Mycobacterium tuberculosis (Mtb) is an ancient disease that has
remained a leading cause of infectious death. Mtb has evolved drug resistance to every …

Antibiotic resistance is a significant threat to public health worldwide. Genome-wide
association studies (GWAS) have emerged as a powerful tool to identify genetic variants …