Translation termination in eukaryotes occurs in response to a stop codon in the ribosomal A-
site and requires two release factors (RFs), eRF1 and eRF3, which bind to the A-site as an …

Ten percent of inherited diseases are caused by premature termination codon (PTC)
mutations that lead to degradation of the mRNA template and to the production of a non …

The ribosome-associated quality control (RQC) pathway degrades nascent chains (NCs)
arising from interrupted translation. First, recycling factors split stalled ribosomes, yielding …

Eukaryotic translation termination results from the complex functional interplay between two
release factors, eRF1 and eRF3, in which GTP hydrolysis by eRF3 couples codon …

Peptide release, the reaction that hydrolyzes a completed protein from the peptidyl-tRNA
upon completion of translation, is catalyzed in the active site of the large subunit of the …

A comparative proteomic analysis was performed to explore the mechanism of cell
elongation in developing cotton fibers. The temporal changes of global proteomes at five …

Eukaryotic release factor eRF1, encoded by the ETF1 gene, recognizes stop codons and
induces peptide release during translation termination. ETF1 produces several different …

Termination of translation in eukaryotes is triggered by two polypeptide chain release
factors, eukaryotic class 1 polypeptide chain release factor (eRF1) and eukaryotic class 2 …

Translation termination is usually a very efficient process. When a stop codon enters the
ribosomal A-site it is recognized by the termination complex which promotes release of the …

Williams-Beuren syndrome (WBS) is a genetic disorder associated with the hemizygous
deletion of several genes in chromosome 7, encoding 26 proteins. Malfunction of these …