The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …

Abstract Kinases of the Jak ('Janus kinase') family and transcription factors (TFs) of the STAT
('signal transducer and activator of transcription') family constitute a rapid membrane-to …

BACKGROUND Reprogramming of host metabolism supports viral pathogenesis by fueling
viral proliferation, by providing, for example, free amino acids and fatty acids as building …

Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during
infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the …

T cell engineering is a powerful means to rapidly generate anti-tumor T cells. The
costimulatory properties of second-generation chimeric antigen receptors (CARs) determine …

The adoptive transfer of chimeric antigen receptor (CAR) T cells represents a breakthrough
in clinical oncology, yet both between-and within-patient differences in autologously derived …

Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the
development of innate and adaptive immune responses. Canonical type I IFN signalling …

The immune system is tasked with identifying malignant cells to eliminate or prevent cancer
spread. This involves a complex orchestration of many immune cell types that together …

Over 5 million people around the world have tested positive for the beta coronavirus SARS-
CoV-2 as of May 29, 2020, a third of which are in the United States alone. These infections …

During an infection, T cells can differentiate into multiple types of effector and memory T
cells, which help to mediate pathogen clearance and provide long-term protective immunity …