Krüppel‐like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested
that KLF5 regulates the expression of a large number of new target genes and participates …

Despite the development of cancer therapies, the success of most treatments has been
impeded by drug resistance. The crucial role of tumor cell plasticity has emerged recently in …

Advanced prostate cancer (PCa) often develops bone metastasis, for which therapies are
very limited and the underlying mechanisms are poorly understood. We report that bone …

High levels of urinary lactate are an increased risk of progression in patients with diabetic
kidney disease (DKD). However, it is still unveiled how lactate drive DKD. Epithelial …

Cell-cell junctions, and specifically desmosomes, are crucial for robust intercellular
adhesion. Desmosomal function is compromised in the autoimmune blistering skin disease …

Basal-like breast cancer (BLBC) accounts for approximately 15% of all breast cancer cases,
and patients with BLBC have a low survival rate. Our previous study demonstrated that the …

Background: Immune checkpoint blockers (ICBs) are revolutionized therapeutic strategies
for cancer, but most patients with solid neoplasms remain resistant to ICBs, partly because of …

An increasing body of evidence suggests that long noncoding RNAs play critical roles in
human cancer. Breast cancer is a heterogeneous disease and the potential involvement of …

Skeletal muscular atrophy is a complex disease involving a large number of gene
expression regulatory networks and various biological processes. Despite extensive …

Prostate cancer is the second leading cause of cancer-related death in the United States. As
a first line treatment for hormone-refractory prostate cancer, docetaxel (DTX) treatment leads …