With the development of the times, cardiovascular diseases have become the biggest cause
of death in the global aging society, causing a serious social burden. Atherosclerosis is a …

Varying from other identified cell death pathways, cuproptosis is a new type of regulated cell
death characterized by excess Cu ions, abnormal aggregation of lipoylated proteins in TCA …

Cerebral palsy is a neurodevelopmental disease characterized by postural, motor, and
cognitive disorders, being one of the main causes of physical and intellectual disability in …

Dual inhibitors of HER2 and EGFR, such as lapatinib, have shown significant efficacy for the
therapy of HER2-positive breast cancer. Previous experiments showed that in cell cultures …

Dexamethasone (DEXA) is a commonly used steroid drug with immunosuppressive and
analgesic properties. Unfortunately, long-term exposure to DEXA severely impairs brain …

Background Chronic stress promotes the development of atherosclerosis, causing
disruptions in the body's hormone levels and changes in the structural function of organs …

Citrate synthase is a crucial enzyme in the TCA cycle and represents a potential therapeutic
target. However, knowledge about this enzyme in Leishmania parasites remains limited. In …

Ubiquitin-specific protease 13 (USP13) is one of the most important deubiquitinases
involved in various diseases. As deubiquitinases are components of the deubiquitination …

A/J mouse is a typical animal model of age-related deafness. Previous studies have shown
that the mice suffer from progressive hearing loss and degeneration of cochlear cells, and a …

Renalase (RNLS) is a recently discovered protein that plays an important role in the
regulation of blood pressure by acting inside and outside cells. Intracellular RNLS is a FAD …