The functional loss of adult stem cells is a major cause of aging and age-related diseases.
Changes in the stem cell niche, increased energy metabolic rate, and accumulation of cell …

The intake of dietary protein regulates growth, metabolism, fecundity and lifespan across
various species, which makes amino acid (AA)-sensing vital for adaptation to the nutritional …

The balance between self-renewal and differentiation ensures long-term maintenance of
stem cell (SC) pools in regenerating epithelial tissues. This balance is challenged during …

Metabolic diseases such as type 2 diabetes are associated with increased cancer incidence.
Here, we show that hyperinsulinemia promotes epithelial tumorigenesis by abrogating cell …

The molecular mechanisms regulating animal tissue size during development are unclear.
This question has been extensively studied in the Drosophila wing disc. Although cell …

Preserving a large number of essential yet highly unstable ribosomal DNA (rDNA) repeats is
critical for the germline to perpetuate the genome through generations. Spontaneous rDNA …

Ribosomal defects perturb stem cell differentiation, and this is the cause of ribosomopathies.
How ribosome levels control stem cell differentiation is not fully known. Here, we discover …

Mutations in the tumor-suppressor Hippo pathway lead to activation of the transcriptional
coactivator Yorkie (Yki), which enhances cell proliferation autonomously and causes cell …

Organ size is regulated by intercellular signaling for cell growth and proliferation. The TOR
pathway mediates a key signaling mechanism for controlling cell size and number in organ …

The proper accumulation and maintenance of stem cells is critical for organ development
and homeostasis. The Notch signaling pathway maintains stem cells in diverse organisms …