The predominantly animal-centric approach of chemical safety assessment has increasingly
come under pressure. Society is questioning overall performance, sustainability, continued …

While human regulatory risk assessment (RA) still largely relies on animal studies, new
approach methodologies (NAMs) based on in vitro, in silico or non-mammalian alternative …

Humans are involuntarily exposed to hundreds of chemicals that either contaminate our
environment and food or are added intentionally to our daily products. These complex …

This paper reviews key elements in the assessment of human health effects from combined
exposure to multiple chemicals taking into consideration current knowledge and challenges …

Considering the chemical complexity and toxicity data gaps of environmental mixtures, most
studies evaluate the chemical risk individually. However, humans are usually exposed to a …

The US Environmental Protection Agency (EPA) is currently conducting separate Toxic
Substances Control Act (TSCA) risk evaluations for seven phthalates: dibutyl phthalate …

Background: There is growing interest in evidence-based interventions, programs, and
policies to mitigate exposures to bisphenols and phthalates and in using implementation …

The exposure assessment component of a Wildlife Ecological Risk Assessment aims to
estimate the magnitude, frequency, and duration of exposure to a chemical or environmental …

Whole mixture-based testing using in vitro new approach methodologies (NAMs) has been
suggested to facilitate the hazard and risk assessment of complex environmental mixtures …

The adverse outcome pathways (AOPs) were developed to accelerate evidence-based
chemical risk assessment by leveraging data from new approach methodologies. Thanks to …